2,3-dimethoxy-5-<3-<<(4-methylphenyl)sulfonyl>oxy>propyl>benzoic acid, methyl ester

Base Information

Chemical Name:2,3-dimethoxy-5-<3-<<(4-methylphenyl)sulfonyl>oxy>propyl>benzoic acid, methyl ester
CAS No.:133129-49-4
Molecular Formula:C₂₀H₂₄O₇S
Molecular Weight:408.472
Hs Code.:

Synonyms:2,3-dimethoxy-5-<3-<<(4-methylphenyl)sulfonyl>oxy>propyl>benzoic acid, methyl ester

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Chemical Property of 2,3-dimethoxy-5-<3-<<(4-methylphenyl)sulfonyl>oxy>propyl>benzoic acid, methyl ester

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Technology Process of 2,3-dimethoxy-5-<3-<<(4-methylphenyl)sulfonyl>oxy>propyl>benzoic acid, methyl ester

There total 5 articles about 2,3-dimethoxy-5-<3-<<(4-methylphenyl)sulfonyl>oxy>propyl>benzoic acid, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 133129-48-3
2,3-dimethoxy-5-(3-hydroxypropyl)benzoic acid, methyl ester

: 98-59-9
p-toluenesulfonyl chloride

: 133129-49-4
2,3-dimethoxy-5-<3-<<(4-methylphenyl)sulfonyl>oxy>propyl>benzoic acid, methyl ester

Guidance literature:: With pyridine; In dichloromethane; at 2 ℃; for 24h;
DOI:10.1021/jm00109a013

Reference yield:

: 877-22-5
3-methoxysalicylic acid

: 133129-49-4
2,3-dimethoxy-5-<3-<<(4-methylphenyl)sulfonyl>oxy>propyl>benzoic acid, methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 92 percent / 18 M H₂SO₄ / 58 h / Heating

2: 93 percent / K₂CO₃ / acetone / 12 h / Heating

3: 92 percent / 0.75 h

4: 95 percent / K₂CO₃ / acetone / 17 h / Heating

5: 1.) 9-borabicyclo<3.3.1>nonane (9-BBN), 2.) 1 M NaOH, 30percent aq. H₂O₂ / 1.) THF, a) 0 deg C, 40 min, b) RT, 40 min, 2.) a) 0 deg C, 30 min, b) RT, 30 min

6: 83 percent / pyridine / CH₂Cl₂ / 24 h / 2 °C

With pyridine; sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; sulfuric acid; dihydrogen peroxide; potassium carbonate; In dichloromethane; acetone;
DOI:10.1021/jm00109a013

Reference yield:

: 6342-70-7
3-methoxymethylsalicylate

: 133129-49-4
2,3-dimethoxy-5-<3-<<(4-methylphenyl)sulfonyl>oxy>propyl>benzoic acid, methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / K₂CO₃ / acetone / 12 h / Heating

2: 92 percent / 0.75 h

3: 95 percent / K₂CO₃ / acetone / 17 h / Heating

4: 1.) 9-borabicyclo<3.3.1>nonane (9-BBN), 2.) 1 M NaOH, 30percent aq. H₂O₂ / 1.) THF, a) 0 deg C, 40 min, b) RT, 40 min, 2.) a) 0 deg C, 30 min, b) RT, 30 min

5: 83 percent / pyridine / CH₂Cl₂ / 24 h / 2 °C

With pyridine; sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; dihydrogen peroxide; potassium carbonate; In dichloromethane; acetone;
DOI:10.1021/jm00109a013