5-piperidin-1-ylpentanoic acid (4-{4-[(benzylmethylamino)methyl]benzoyl}phenyl)amide

Base Information

• Chemical Name: 5-piperidin-1-ylpentanoic acid (4-{4-[(benzylmethylamino)methyl]benzoyl}phenyl)amide
• CAS No.: 1298055-85-2
• Molecular Formula: C₃₂H₃₉N₃O₂
• Molecular Weight: 497.681
• Mol file: 1298055-85-2.mol

Synonyms:5-piperidin-1-ylpentanoic acid (4-{4-[(benzylmethylamino)methyl]benzoyl}phenyl)amide

Chemical Property of 5-piperidin-1-ylpentanoic acid (4-{4-[(benzylmethylamino)methyl]benzoyl}phenyl)amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-piperidin-1-ylpentanoic acid (4-{4-[(benzylmethylamino)methyl]benzoyl}phenyl)amide

There total 5 articles about 5-piperidin-1-ylpentanoic acid (4-{4-[(benzylmethylamino)methyl]benzoyl}phenyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

piperidine (110-89-4) + 5-chloropentanoic acid (4-{4-[(benzylmethylamino)methyl]benzoyl}phenyl)amide (1298055-73-8) → 5-piperidin-1-ylpentanoic acid (4-{4-[(benzylmethylamino)methyl]benzoyl}phenyl)amide (1298055-85-2)

Guidance literature:

In propan-1-ol; for 8h; Reflux;

DOI:10.1016/j.ejmech.2011.02.019

Reference yield:

(4-((benzyl(methyl)amino)methyl)phenyl)(4-nitrophenyl)methanone (1298055-70-5) → 5-piperidin-1-ylpentanoic acid (4-{4-[(benzylmethylamino)methyl]benzoyl}phenyl)amide (1298055-85-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 10% Pd/CaCO3; hydrogen / tetrahydrofuran / 20 °C

2: acetonitrile / 6 h / Reflux

3: propan-1-ol / 8 h / Reflux

With 10% Pd/CaCO3; hydrogen; In tetrahydrofuran; propan-1-ol; acetonitrile;

DOI:10.1016/j.ejmech.2011.02.019

Reference yield:

(4-methylphenyl)(4-nitrophenyl)methanone (5350-47-0) → 5-piperidin-1-ylpentanoic acid (4-{4-[(benzylmethylamino)methyl]benzoyl}phenyl)amide (1298055-85-2)

Guidance literature:

Multi-step reaction with 5 steps

1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 6 h / 60 °C

2: triethylamine / toluene / 12 h / Reflux

3: 10% Pd/CaCO3; hydrogen / tetrahydrofuran / 20 °C

4: acetonitrile / 6 h / Reflux

5: propan-1-ol / 8 h / Reflux

With N-Bromosuccinimide; 10% Pd/CaCO3; hydrogen; triethylamine; dibenzoyl peroxide; In tetrahydrofuran; propan-1-ol; tetrachloromethane; toluene; acetonitrile;

DOI:10.1016/j.ejmech.2011.02.019

upstream raw materials:

piperidine

5-chloropentanoic acid (4-{4-[(benzylmethylamino)methyl]benzoyl}phenyl)amide

(4-((benzyl(methyl)amino)methyl)phenyl)(4-nitrophenyl)methanone

(4-aminophenyl)(4-((benzyl(methyl)amino)methyl)phenyl)methanone