Technology Process of 3-(3-benzyloxy-17β-hydroxyestra-1,3,5(10)-trien-15α-yl)propanoic acid
There total 10 articles about 3-(3-benzyloxy-17β-hydroxyestra-1,3,5(10)-trien-15α-yl)propanoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium hydroxide;
In
methanol;
at 55 ℃;
for 3h;
DOI:10.1021/jm0204340
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 97 percent / K2CO3; diisopropylethylamine / acetone / 72 h / 20 °C
2.1: 52 percent / pTsOH / acetone; H2O / 1.5 h / 20 °C
3.1: 73 percent / tetrahydrofuran / 3 h / 0 °C
4.1: 80 percent / KH; 18-crown-6 / tetrahydrofuran / 3 h / 20 °C
5.1: 91 percent / NaBH4 / tetrahydrofuran; H2O / 3 h / 20 °C
6.1: 94 percent / pyridine / 17 h / 20 °C
7.1: BH3 / tetrahydrofuran / 2 h / 20 °C
7.2: 82 percent / trimethylamine N-oxide dihydrate / tetrahydrofuran; ethanol; bis-(2-methoxy-ethyl) ether / 1 h / 150 °C
8.1: 213 mg / CrO3; H2SO4 / acetone / 0.33 h / 0 °C
9.1: 134 mg / aq. KOH / methanol / 3 h / 55 °C
With
pyridine; chromium(VI) oxide; potassium hydroxide; sodium tetrahydroborate; 18-crown-6 ether; sulfuric acid; borane; potassium hydride; potassium carbonate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; water; acetone;
4.1: oxy-Cope rearrangement;
DOI:10.1021/jm0204340
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 52 percent / pTsOH / acetone; H2O / 1.5 h / 20 °C
2.1: 73 percent / tetrahydrofuran / 3 h / 0 °C
3.1: 80 percent / KH; 18-crown-6 / tetrahydrofuran / 3 h / 20 °C
4.1: 91 percent / NaBH4 / tetrahydrofuran; H2O / 3 h / 20 °C
5.1: 94 percent / pyridine / 17 h / 20 °C
6.1: BH3 / tetrahydrofuran / 2 h / 20 °C
6.2: 82 percent / trimethylamine N-oxide dihydrate / tetrahydrofuran; ethanol; bis-(2-methoxy-ethyl) ether / 1 h / 150 °C
7.1: 213 mg / CrO3; H2SO4 / acetone / 0.33 h / 0 °C
8.1: 134 mg / aq. KOH / methanol / 3 h / 55 °C
With
pyridine; chromium(VI) oxide; potassium hydroxide; sodium tetrahydroborate; 18-crown-6 ether; sulfuric acid; borane; potassium hydride; toluene-4-sulfonic acid;
In
tetrahydrofuran; methanol; water; acetone;
3.1: oxy-Cope rearrangement;
DOI:10.1021/jm0204340
