17β-hydroxy-17α-(trimethylsilylprop-2-enyl)androst-4-en-3-one

Base Information

• Chemical Name: 17β-hydroxy-17α-(trimethylsilylprop-2-enyl)androst-4-en-3-one
• CAS No.: 74137-32-9
• Molecular Formula: C₂₅H₄₀O₂Si
• Molecular Weight: 400.677
• Mol file: 74137-32-9.mol

Synonyms:17β-hydroxy-17α-(trimethylsilylprop-2-enyl)androst-4-en-3-one

Chemical Property of 17β-hydroxy-17α-(trimethylsilylprop-2-enyl)androst-4-en-3-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 17β-hydroxy-17α-(trimethylsilylprop-2-enyl)androst-4-en-3-one

There total 1 articles about 17β-hydroxy-17α-(trimethylsilylprop-2-enyl)androst-4-en-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 1.0%

(8R,9S,10R,13S,14S,17R)-3-Methoxy-10,13-dimethyl-17-((E)-3-trimethylsilanyl-allyl)-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-ol (74137-34-1) → testosterone (58-22-0) + 17β-hydroxy-17α-(trimethylsilylprop-2-enyl)androst-4-en-3-one (74137-32-9)

Guidance literature:

With acid;

DOI:10.1016/S0040-4039(00)93611-6

Reference yield:

17β-hydroxy-17α-(trimethylsilylprop-2-enyl)androst-4-en-3-one (74137-32-9) → 3-oxopregn-4-ene-21,17α-carbolactone (976-70-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / VO(acac)2, tert-butyl hydroperoxide / benzene / Heating

2: 93 percent / BF₃*Et₂O / methanol / 24 h / Ambient temperature

3: 48 percent / Jones reagent / acetone / 0.5 h / 0 °C

With tert.-butylhydroperoxide; jones reagent; bis(acetylacetonate)oxovanadium; boron trifluoride diethyl etherate; In methanol; acetone; benzene;

DOI:10.1021/ja00535a600

upstream raw materials:

(8R,9S,10R,13S,14S,17R)-3-Methoxy-10,13-dimethyl-17-((E)-3-trimethylsilanyl-allyl)-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-ol

Downstream raw materials:

3-oxopregn-4-ene-21,17α-carbolactone