976-70-5

Basic information

• Product Name: 3-oxopregn-4-ene-21,17alpha-carbolactone
• Synonyms: 3-oxopregn-4-ene-21,17alpha-carbolactone;17-hydroxy-3-oxo-17-alpha-pregn-4-ene-21-carboxylic aci gamma-lactone;20-spirox-4-ene-3,20-dione;3-(3-oxo-17-beta-hydroxy-4-androsten-17-alpha-yl)propionic acid gamma-lactone;17alpha-(2-carboxyethyl)testosterone gamma-lactone;(17R)-17-Hydroxy-3-oxopregn-4-ene-21-carboxylic acid γ-lactone;(17R)-3-Oxo-17-hydroxypregn-4-ene-21-carboxylic acid γ-lactone;6,7-Dihydrocanrenone
• CAS NO: 976-70-5
• Molecular Formula: C₂₂H₃₀O₃
• Molecular Weight: 342.4718
• EINECS: 213-552-4
• Mol File: 976-70-5.mol
• Article Data: 11

Chemical Properties

• Melting Point: 156-159 °C
• Boiling Point: 522.8±50.0 °C(Predicted)
• Appearance: /
• Density: 1.17±0.1 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, Refrigerator, Under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• Water Solubility: 20.4mg/L at 20℃
• Stability: Hygroscopic
• CAS DataBase Reference: 3-oxopregn-4-ene-21,17alpha-carbolactone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-oxopregn-4-ene-21,17alpha-carbolactone(976-70-5)
• EPA Substance Registry System: 3-oxopregn-4-ene-21,17alpha-carbolactone(976-70-5)

Safety Data

• Hazardous Substances Data: 976-70-5(Hazardous Substances Data)

Usage

Uses

6,7-Dihydrocanrenone (Spironolactone EP Impurity C) is an intermediate in the synthesis of Canrenone (C175610), an aldosterone antagonist. Diuretic.

Upstream product

• 50407-76-6 17α-ethynyl-17β-hydroxy-5-androsten-3-one ethylene ketal 
• 63-05-8 Androstenedione 
• 55542-26-2 17,23-dihydroxy-21,24-dinor-17βH-chol-4-en-20-yn-3-one 
• 55542-27-3 17α-(3-hydroxypropyl)-17β-hydroxy-4-androsten-3-one 
• 74137-34-1 (8R,9S,10R,13S,14S,17R)-3-Methoxy-10,13-dimethyl-17-((E)-3-trimethylsilanyl-allyl)-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-ol 
• 74137-33-0 17β-hydroxy-17α-(2,3-epoxy-3-trimethylsilylpropyl)androst-4-en-3-one 
• 74137-32-9 17β-hydroxy-17α-(trimethylsilylprop-2-enyl)androst-4-en-3-one 
• 57144-06-6 3-methoxyandrosta-3,5-dien-17-one 
• 121936-43-4 5'-hydroxyspiro-5-en-3-one 
• 434-03-7 levonorgestrel 
• 3754-63-0 3,3-ethylenedioxy-5-androsten-17-one 
• 975-57-5 3,3-(ethylenedioxy)-5-androsten-17β-ol 
• 169306-24-5 3-(3',3'-(ethylenedithio)-17'β-hydroxy-4'-androsten-17'α-yl)propionitrile 
• 169306-23-4 3,3-(ethylenedithio)spiro<4-androstene-17,2'-oxirane> 

Downstream Products

• 52-01-7 SPIRONOLACTONE 
• 976-71-6 Canrenone 
• 63815-34-9 6,7-dihydrocanrenonoic acid 
• 976-71-6 canrenone 

Relevant articles and documents

Synthesis process of steroid compound, canrenone and spirolactone

The invention relates to the technical field of medicine synthesis, in particular to a synthesis process of a steroid compound, canrenone and spirolactone. An embodiment of the invention provides thesteroid compound. The steroid compound has a structural formula as shown in the specification. In the structural formula, R is selected from H or an alkyl group. The steroid compound can be used for synthesizing canrenone and spirolactone, synthesis conditions are mild, synthesis efficiency is high, the amount of wastewater is small, the quality of the formed products is high, and production costcan be effectively reduced.

Having a method for the synthesis of intermediates spirondactone

The invention relates to a synthesis method of a chemical medicine, and concretely relates to a synthesis method of a spironolactone intermediate canrenone. The method comprises the following steps: carrying out an ethynylation reaction on a compound I 4-androstenedione (4AD), hydrogenating, carrying out an oxidation cyclization reaction, and carrying out a bromization and debromination reaction to obtain the compound V canrenone, and the above reaction route is shown in the specification. A synthesis method of the structure of an important 21,17-carboxy lactone spiro ring adopted in the invention is different from previous process modes, and is concise and efficient. The method has the characteristics of high yield, good selectivity, low cost, mild reactions, suitableness for industrialization, stability and easy realization.

A Novel Synthesis of Spironolactone. An Application of the Hydroformylation Reaction

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