4-iodo-2-isobutylphenyl trifluoromethanesulfonate

Base Information

• Chemical Name: 4-iodo-2-isobutylphenyl trifluoromethanesulfonate
• CAS No.: 1426943-12-5
• Molecular Formula: C₁₁H₁₂F₃IO₃S
• Molecular Weight: 408.18
• Mol file: 1426943-12-5.mol

Synonyms:4-iodo-2-isobutylphenyl trifluoromethanesulfonate

Chemical Property of 4-iodo-2-isobutylphenyl trifluoromethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 4-iodo-2-isobutylphenyl trifluoromethanesulfonate

There total 4 articles about 4-iodo-2-isobutylphenyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

trifluoromethylsulfonic anhydride (358-23-6) + 4-iodo-2-isobutylphenol (475272-56-1) → 4-iodo-2-isobutylphenyl trifluoromethanesulfonate (1426943-12-5)

Guidance literature:

With pyridine; at 0 - 20 ℃; for 24h; Inert atmosphere; Schlenk technique;

DOI:10.1002/chem.201203005

Reference yield:

2-isobutylphenol (4167-75-3) → 4-iodo-2-isobutylphenyl trifluoromethanesulfonate (1426943-12-5)

Guidance literature:

Multi-step reaction with 2 steps

1: Iodine monochloride / acetic acid / 48 h / 20 °C

2: pyridine / 24 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

With pyridine; Iodine monochloride; In acetic acid;

DOI:10.1002/chem.201203005

Reference yield:

methylallyl phenyl ether (5820-22-4) → 4-iodo-2-isobutylphenyl trifluoromethanesulfonate (1426943-12-5)

Guidance literature:

Multi-step reaction with 4 steps

1: N,N-dimethyl acetamide / 120 h / 190 °C / Sealed tube

2: nickel; hydrogen / methanol / 24 h / 60 °C / 45004.5 Torr

3: acetic acid; Iodine monochloride / 48 h / 20 °C

4: pyridine / 2 h / 0 - 20 °C

With pyridine; hydrogen; Iodine monochloride; nickel; acetic acid; In methanol; N,N-dimethyl acetamide; 1: |Claisen Rearrangement;

DOI:10.1007/s00706-015-1599-0

upstream raw materials:

2-(2-methyl-1-propenyl)phenol

2-isobutylphenol

trifluoromethylsulfonic anhydride

4-iodo-2-isobutylphenol

Downstream raw materials:

3''-benzyl-2'-isobutyl-3-isopropyl[1,1':4',1'']terphenyl

Refernces

• 1、 Peters, Martin,Trobe, Melanie,Tan, Hao,Kleineweischede, Rolf,Breinbauer, Rolf. "A modular synthesis of teraryl-based α-helix mimetics, part 1: Synthesis of core fragments with two electronically differentiated leaving groups". . p. 2442 - 2449. Retrieved 2013/04/24.