4-iodo-2-isobutylphenol

Base Information

• Chemical Name: 4-iodo-2-isobutylphenol
• CAS No.: 475272-56-1
• Molecular Formula: C₁₀H₁₃IO
• Molecular Weight: 276.117
• Mol file: 475272-56-1.mol

Synonyms:4-iodo-2-isobutylphenol

Chemical Property of 4-iodo-2-isobutylphenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 4-iodo-2-isobutylphenol

There total 4 articles about 4-iodo-2-isobutylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-isobutylphenol (4167-75-3) → 4-iodo-2-isobutylphenol (475272-56-1)

Guidance literature:

With Iodine monochloride; In acetic acid; at 20 ℃; for 48h;

DOI:10.1002/chem.201203005

Reference yield:

isopropylboronic acid (80041-89-0) + C14H13IN2O3S → 4-iodo-2-isobutylphenol (475272-56-1)

Guidance literature:

With caesium carbonate; In 1,4-dioxane; at 110 ℃; for 12h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.0c00471

Reference yield:

methylallyl phenyl ether (5820-22-4) → 4-iodo-2-isobutylphenol (475272-56-1)

Guidance literature:

Multi-step reaction with 3 steps

1: N,N-dimethyl acetamide / 120 h / 190 °C / Sealed tube

2: nickel; hydrogen / methanol / 24 h / 60 °C / 45004.5 Torr

3: acetic acid; Iodine monochloride / 48 h / 20 °C

With hydrogen; Iodine monochloride; nickel; acetic acid; In methanol; N,N-dimethyl acetamide; 1: |Claisen Rearrangement;

DOI:10.1007/s00706-015-1599-0

upstream raw materials:

2-(2-methyl-1-propenyl)phenol

2-isobutylphenol

methylallyl phenyl ether

isopropylboronic acid

Downstream raw materials:

3''-benzyl-2'-isobutyl-3-isopropyl[1,1':4',1'']terphenyl

4-iodo-2-isobutylphenyl trifluoromethanesulfonate

Refernces

• 1、 Trobe, Melanie,Breinbauer, Rolf. "Improved and scalable synthesis of building blocks for the modular synthesis of teraryl-based alpha-helix mimetics". . p. 509 - 521. Retrieved 2016/03/19.