2-(4-([bis(1H-imidazol-2-ylmethyl)amino]methyl)benzyl)-8-(1-ethylpropyl)-2,8-diazaspiro[4.5]decane-1-carboxylic acid

Base Information

Chemical Name:2-(4-([bis(1H-imidazol-2-ylmethyl)amino]methyl)benzyl)-8-(1-ethylpropyl)-2,8-diazaspiro[4.5]decane-1-carboxylic acid
CAS No.:1259040-25-9
Molecular Formula:C₃₀H₄₃N₇O₂
Molecular Weight:533.717
Hs Code.:

Synonyms:2-(4-([bis(1H-imidazol-2-ylmethyl)amino]methyl)benzyl)-8-(1-ethylpropyl)-2,8-diazaspiro[4.5]decane-1-carboxylic acid

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Chemical Property of 2-(4-([bis(1H-imidazol-2-ylmethyl)amino]methyl)benzyl)-8-(1-ethylpropyl)-2,8-diazaspiro[4.5]decane-1-carboxylic acid

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Technology Process of 2-(4-([bis(1H-imidazol-2-ylmethyl)amino]methyl)benzyl)-8-(1-ethylpropyl)-2,8-diazaspiro[4.5]decane-1-carboxylic acid

There total 17 articles about 2-(4-([bis(1H-imidazol-2-ylmethyl)amino]methyl)benzyl)-8-(1-ethylpropyl)-2,8-diazaspiro[4.5]decane-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1259040-36-2
C₃₁H₄₅N₇O₂

: 1259040-25-9
2-(4-([bis(1H-imidazol-2-ylmethyl)amino]methyl)benzyl)-8-(1-ethylpropyl)-2,8-diazaspiro[4.5]decane-1-carboxylic acid

Guidance literature:: C₃₁H₄₅N₇O₂; With ethanol; sodium hydroxide; at 70 - 80 ℃; for 47h;

With hydrogenchloride; In ethanol; water;

Reference yield:

: 146603-99-8
1-(1,1-dimethylethyl) 4-ethyl 4-(2-propenyl)-1,4-piperidinedicarboxylate

: 1259040-25-9
2-(4-([bis(1H-imidazol-2-ylmethyl)amino]methyl)benzyl)-8-(1-ethylpropyl)-2,8-diazaspiro[4.5]decane-1-carboxylic acid

Guidance literature:: Multi-step reaction with 15 steps

1.1: ozone / methanol / 1 h / -78 °C

1.2: 15 h / 20 °C

2.1: acetic acid; sodium tris(acetoxy)borohydride / N,N-dimethyl-formamide / 21 h / 20 - 40 °C / Inert atmosphere

3.1: diisobutylaluminium hydride / tetrahydrofuran / 2 h / -40 °C / Inert atmosphere

3.2: 0.5 h / -40 - 20 °C

4.1: lithium diisopropyl amide; N,N,N,N,N,N-hexamethylphosphoric triamide / n-heptane; tetrahydrofuran; ethylbenzene / 0.08 h / -78 °C / Inert atmosphere

4.2: 1.5 h

5.1: water; sodium tetrahydroborate / ethanol / 5 h / 20 °C

6.1: hydrogen / 10 wt% Pd(OH)2 on carbon / ethanol / 3 h / 60 °C

7.1: sodium carbonate / tetrahydrofuran / 3 h

8.1: triethanolamine; pyridine-SO₃ complex; dimethyl sulfoxide / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere

9.1: 2-methyl-but-2-ene; sodium hypochlorite; sodium dihydrogenphosphate / water; tert-butyl alcohol / 2.25 h / 20 °C

9.2: 0.02 h

10.1: hydrogen / 10 wt% Pd(OH)2 on carbon / ethanol / 0.5 h / 20 °C

11.1: water; α-picoline-borane / methanol / 4 h

12.1: water; sulfuric acid / methanol / 18 h / 0 - 20 °C

13.1: titanium(IV) tetraethanolate / tetrahydrofuran / 1 h / 50 °C / Inert atmosphere

13.2: 1 h / 20 °C

14.1: hydrogenchloride / methanol / 15 h / 40 °C

15.1: sodium hydroxide; ethanol / 47 h / 70 - 80 °C

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; titanium(IV) tetraethanolate; sodium hypochlorite; sodium tetrahydroborate; sodium dihydrogenphosphate; 2-methyl-but-2-ene; pyridine-SO₃ complex; triethanolamine; ethanol; sulfuric acid; α-picoline-borane; water; hydrogen; sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; sodium carbonate; ozone; acetic acid; dimethyl sulfoxide; sodium hydroxide; lithium diisopropyl amide; 10 wt% Pd(OH)2 on carbon; In tetrahydrofuran; methanol; ethanol; n-heptane; dichloromethane; ethylbenzene; water; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 1228603-43-7
4-(2-oxoethyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

: 1259040-25-9
2-(4-([bis(1H-imidazol-2-ylmethyl)amino]methyl)benzyl)-8-(1-ethylpropyl)-2,8-diazaspiro[4.5]decane-1-carboxylic acid

Guidance literature:: Multi-step reaction with 14 steps

1.1: acetic acid; sodium tris(acetoxy)borohydride / N,N-dimethyl-formamide / 21 h / 20 - 40 °C / Inert atmosphere

2.1: diisobutylaluminium hydride / tetrahydrofuran / 2 h / -40 °C / Inert atmosphere

2.2: 0.5 h / -40 - 20 °C

3.1: lithium diisopropyl amide; N,N,N,N,N,N-hexamethylphosphoric triamide / n-heptane; tetrahydrofuran; ethylbenzene / 0.08 h / -78 °C / Inert atmosphere

3.2: 1.5 h

4.1: water; sodium tetrahydroborate / ethanol / 5 h / 20 °C

5.1: hydrogen / 10 wt% Pd(OH)2 on carbon / ethanol / 3 h / 60 °C

6.1: sodium carbonate / tetrahydrofuran / 3 h

7.1: triethanolamine; pyridine-SO₃ complex; dimethyl sulfoxide / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere

8.1: 2-methyl-but-2-ene; sodium hypochlorite; sodium dihydrogenphosphate / water; tert-butyl alcohol / 2.25 h / 20 °C

8.2: 0.02 h

9.1: hydrogen / 10 wt% Pd(OH)2 on carbon / ethanol / 0.5 h / 20 °C

10.1: water; α-picoline-borane / methanol / 4 h

11.1: water; sulfuric acid / methanol / 18 h / 0 - 20 °C

12.1: titanium(IV) tetraethanolate / tetrahydrofuran / 1 h / 50 °C / Inert atmosphere

12.2: 1 h / 20 °C

13.1: hydrogenchloride / methanol / 15 h / 40 °C

14.1: sodium hydroxide; ethanol / 47 h / 70 - 80 °C

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; titanium(IV) tetraethanolate; sodium hypochlorite; sodium tetrahydroborate; sodium dihydrogenphosphate; 2-methyl-but-2-ene; pyridine-SO₃ complex; triethanolamine; ethanol; sulfuric acid; α-picoline-borane; water; hydrogen; sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; sodium carbonate; acetic acid; dimethyl sulfoxide; sodium hydroxide; lithium diisopropyl amide; 10 wt% Pd(OH)2 on carbon; In tetrahydrofuran; methanol; ethanol; n-heptane; dichloromethane; ethylbenzene; water; N,N-dimethyl-formamide; tert-butyl alcohol;