146603-99-8

Basic information

• Product Name: 1,4-Piperidinedicarboxylic acid, 4-(2-propen-1-yl)-, 1-(1,1-dimethylethyl) 4-ethyl ester
• Synonyms: 1,4-Piperidinedicarboxylic acid, 4-(2-propen-1-yl)-, 1-(1,1-dimethylethyl) 4-ethyl ester;1-tert-butyl 4-ethyl 4-allylpiperidine-1,4-dicarboxylate;1-(1,1-Dimethylethyl) 4-ethyl 4-(2-propenyl)-1,4-piperidinedicarboxylate;Ethyl 4-allyl-1-(tert-butoxycarbonyl)piperidine-4-carboxylate;1,4-Piperidinedicarboxylic acid, 4-(2-propen-1-yl)-;1-Boc-4-allyl-4-ethoxycarbonylpiperidine
• CAS NO: 146603-99-8
• Molecular Formula: C₁₆H₂₇NO₄
• Molecular Weight: 297.39
• Product Categories: Building Blocks;C16 to C36;Chemical Synthesis;Heterocyclic Building Blocks;Piperidines
• Mol File: 146603-99-8.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 130-135℃/1.5mmHg
• Flash Point: >110°C
• Appearance: /
• Density: 1.020g/mLat 25℃
• Vapor Pressure: 2.97E-07mmHg at 25°C
• Refractive Index: n20/D 1.4676
• PKA: -2.29±0.40(Predicted)
• CAS DataBase Reference: 1,4-Piperidinedicarboxylic acid, 4-(2-propen-1-yl)-, 1-(1,1-dimethylethyl) 4-ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Piperidinedicarboxylic acid, 4-(2-propen-1-yl)-, 1-(1,1-dimethylethyl) 4-ethyl ester(146603-99-8)
• EPA Substance Registry System: 1,4-Piperidinedicarboxylic acid, 4-(2-propen-1-yl)-, 1-(1,1-dimethylethyl) 4-ethyl ester(146603-99-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• Hazardous Substances Data: 146603-99-8(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 146603-99-8 differently. You can refer to the following data:
1. Reactant for synthesis of T-type calcium channel antagonists1
2. Ethyl 1-Boc-4-allyl-4-piperidinecarboxylate is an intermediate used in the synthesis of 2,8-diazaspiro[4.5]decanones as T-type calcium channel antagonists.
3. Reactant for synthesis of T-type calcium channel antagonists

InChI:InChI=1/C10H15NO4/c1-2-3-10(8(12)13)4-6-11(7-5-10)9(14)15/h2H,1,3-7H2,(H,12,13)(H,14,15)

Upstream product

• 556-56-9 allyl iodid 
• 142851-03-4 1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate 
• 5162-44-7 1-bromo-4-butene 
• 106-95-6 allyl bromide 

Downstream Products

• 1228603-43-7 4-(2-oxoethyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester 
• 1350445-29-2 2-{4-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl]-2-fluoro-phenyl}-1-oxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester 
• 1350445-33-8 2-[2-fluoro-4-(4-hydroxy-cyclohexyl)-phenyl]-1-oxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester 
• 236406-40-9 tert-butyl 2-benzyl-2,8-diazaspiro[4.5]decane-8-carboxylate 
• 867009-61-8 2-benzyl-2,8-diazaspiro[4.5]decane 
• 716324-44-6 2-benzyl-2,8-diazaspiro[4.5]decan-1-one 
• 236406-39-6 2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester 
• 1186663-51-3 ethyl 4-allylpiperidine-4-carboxylate hydrochloride 
• 1259040-36-2 C₃₁H₄₅N₇O₂ 
• 1259040-35-1 C₃₅H₅₅N₉O₆S₂ 
• 1259040-34-0 C₃₀H₄₅N₉O₆S₂ 

Relevant articles and documents

Preparation method of 4-oxo-8-azaspiro [4.5] dec-2-ene-8-carboxylic acid tert-butyl ester (benzyl ester)

The invention discloses a preparation method of 4-oxo-8-azaspiro [4.5] dec-2-ene-8-carboxylic acid tert-butyl ester (benzyl ester) and an intermediate thereof. The preparation method comprises the following steps: reacting a compound II with 3-bromopropylene under the action of alkali 1 to generate a compound III; dissolving the compound III in a solvent, carrying out cyclization under the action of lithium diisopropylamide, and reacting to generate a compound IV; and under the action of alkali 2, carrying out double bond shift on the compound IV to generate a compound I. The method has the advantages of easily available raw materials, simple operation and high yield, the total yield can reach more than 65%, and the method is suitable for large-scale preparation.

Spirocyclic derivatives

The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease, disorder or condition ameliorated by inhibition of a dopamine transporter); and methods of treating patients with such compounds; wherein R1, R2, R3, R4, R5, R6, R9, R10, Q, X, Y, Z, A, L, B, m, n and p are as defined herein.

ANTIBACTERIAL COMPOUNDS

The present invention provides a compound of the following formula and salts thereof: Also provided is the use of these compounds as antibacterials, compositions comprising them and processes for their manufacture.