phosphoric acid dibenzyl ester 2-(bis-benzyloxy-phosphoryloxy)-6-methoxy-3-(3,4,5-trimethoxy-benzoyl)-phenyl ester

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Chemical Name:phosphoric acid dibenzyl ester 2-(bis-benzyloxy-phosphoryloxy)-6-methoxy-3-(3,4,5-trimethoxy-benzoyl)-phenyl ester
CAS No.:290347-55-6
Molecular Formula:C₄₅H₄₄O₁₃P₂
Molecular Weight:854.784
Hs Code.:

Synonyms:phosphoric acid dibenzyl ester 2-(bis-benzyloxy-phosphoryloxy)-6-methoxy-3-(3,4,5-trimethoxy-benzoyl)-phenyl ester

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Chemical Property of phosphoric acid dibenzyl ester 2-(bis-benzyloxy-phosphoryloxy)-6-methoxy-3-(3,4,5-trimethoxy-benzoyl)-phenyl ester

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Technology Process of phosphoric acid dibenzyl ester 2-(bis-benzyloxy-phosphoryloxy)-6-methoxy-3-(3,4,5-trimethoxy-benzoyl)-phenyl ester

There total 9 articles about phosphoric acid dibenzyl ester 2-(bis-benzyloxy-phosphoryloxy)-6-methoxy-3-(3,4,5-trimethoxy-benzoyl)-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 17176-77-1
Dibenzyl phosphite

: 290347-52-3
(2',3'-dihydroxy-4'-methoxyphenyl)(3,4,5-trimethoxyphenyl)methanone

: 290347-55-6
phosphoric acid dibenzyl ester 2-(bis-benzyloxy-phosphoryloxy)-6-methoxy-3-(3,4,5-trimethoxy-benzoyl)-phenyl ester

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In tetrachloromethane; acetonitrile; at -10 ℃; for 16h;
DOI:10.1021/jm000045a

Reference yield:

: 20035-41-0
6-bromo-2-hydroxy-3-methoxybenzaldehyde

: 290347-55-6
phosphoric acid dibenzyl ester 2-(bis-benzyloxy-phosphoryloxy)-6-methoxy-3-(3,4,5-trimethoxy-benzoyl)-phenyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 64 percent / 30 percent aq. H₂O₂; aq. NaOH

2.1: 91 percent / iPr₂NEt / tetrahydrofuran / 3 h

3.1: nBuLi / tetrahydrofuran / 1 h

3.2: 92 percent / tetrahydrofuran / 4 h

4.1: 96 percent / pyridinium dichromate; 4 Angstroem molecular sieves / CH₂Cl₂

5.1: 97 percent / 1N HCl / methanol / 2 h

6.1: 96 percent / DMAP; iPr₂NEt / CCl₄; acetonitrile / 16 h / -10 °C

With hydrogenchloride; dmap; sodium hydroxide; dipyridinium dichromate; n-butyllithium; 4 A molecular sieve; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; acetonitrile; 1.1: Oxidation / 2.1: Alkylation / 3.1: Metallation / 3.2: Addition / 4.1: Oxidation / 5.1: Acidolysis / 6.1: Phosphorylation;
DOI:10.1021/jm000045a

Reference yield:

: 7150-01-8
2-acetoxy-3-methoxybenzaldehyde

: 290347-55-6
phosphoric acid dibenzyl ester 2-(bis-benzyloxy-phosphoryloxy)-6-methoxy-3-(3,4,5-trimethoxy-benzoyl)-phenyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: 79 percent / Br₂; KBr / H₂O

2.1: 98 percent / aq. NaHCO₃ / methanol / 2 h

3.1: 64 percent / 30 percent aq. H₂O₂; aq. NaOH

4.1: 91 percent / iPr₂NEt / tetrahydrofuran / 3 h

5.1: nBuLi / tetrahydrofuran / 1 h

5.2: 92 percent / tetrahydrofuran / 4 h

6.1: 96 percent / pyridinium dichromate; 4 Angstroem molecular sieves / CH₂Cl₂

7.1: 97 percent / 1N HCl / methanol / 2 h

8.1: 96 percent / DMAP; iPr₂NEt / CCl₄; acetonitrile / 16 h / -10 °C

With hydrogenchloride; dmap; sodium hydroxide; dipyridinium dichromate; n-butyllithium; 4 A molecular sieve; dihydrogen peroxide; bromine; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; potassium bromide; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; water; acetonitrile; 1.1: Bromination / 2.1: Deacetylation / 3.1: Oxidation / 4.1: Alkylation / 5.1: Metallation / 5.2: Addition / 6.1: Oxidation / 7.1: Acidolysis / 8.1: Phosphorylation;
DOI:10.1021/jm000045a