4-[(2R)-2-(3,5-dichlorophenyl)-2-(trifiuoromethyl)-3H-furan-4-yl]-N-(1,1-dioxothietan-3-yl)-2-methylbenzamide

Base Information

Chemical Name:4-[(2R)-2-(3,5-dichlorophenyl)-2-(trifiuoromethyl)-3H-furan-4-yl]-N-(1,1-dioxothietan-3-yl)-2-methylbenzamide
CAS No.:1425943-24-3
Molecular Formula:C₂₂H₁₈Cl₂F₃NO₄S
Molecular Weight:520.356
Hs Code.:

Synonyms:4-[(2R)-2-(3,5-dichlorophenyl)-2-(trifiuoromethyl)-3H-furan-4-yl]-N-(1,1-dioxothietan-3-yl)-2-methylbenzamide

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Chemical Property of 4-[(2R)-2-(3,5-dichlorophenyl)-2-(trifiuoromethyl)-3H-furan-4-yl]-N-(1,1-dioxothietan-3-yl)-2-methylbenzamide

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Technology Process of 4-[(2R)-2-(3,5-dichlorophenyl)-2-(trifiuoromethyl)-3H-furan-4-yl]-N-(1,1-dioxothietan-3-yl)-2-methylbenzamide

There total 14 articles about 4-[(2R)-2-(3,5-dichlorophenyl)-2-(trifiuoromethyl)-3H-furan-4-yl]-N-(1,1-dioxothietan-3-yl)-2-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 88511-13-1
(1,1-dioxo-1λ⁶-thietan-3-yl)amine

: 1331886-83-9
4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-furan-3-yl]-2-methyl-benzoic acid

: 1425943-24-3
4-[(2R)-2-(3,5-dichlorophenyl)-2-(trifiuoromethyl)-3H-furan-4-yl]-N-(1,1-dioxothietan-3-yl)-2-methylbenzamide

: 1425943-23-2
4-[(2S)-2-(3,5-dichloro-phenyl)-2-trifluoromethyl-3H-furan-4-yl]-N-(1,1-dioxo-1λ⁶-thietan-3-yl)-2-methyl-benzamide

Guidance literature:: 4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-furan-3-yl]-2-methyl-benzoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃;

(1,1-dioxo-1λ⁶-thietan-3-yl)amine; With triethylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 130336-16-2
3,5-dichloro-2,2,2-trifluoroacetophenone

: 1425943-24-3
4-[(2R)-2-(3,5-dichlorophenyl)-2-(trifiuoromethyl)-3H-furan-4-yl]-N-(1,1-dioxothietan-3-yl)-2-methylbenzamide

: 1425943-23-2
4-[(2S)-2-(3,5-dichloro-phenyl)-2-trifluoromethyl-3H-furan-4-yl]-N-(1,1-dioxo-1λ⁶-thietan-3-yl)-2-methyl-benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / -75 - 20 °C

2.1: tetrabutylammonium acetate; palladium diacetate / 0.25 h / 80 °C / Inert atmosphere

2.2: 60 h / 80 °C

3.1: dicarbonylacetylacetonato rhodium (I); tris(2,4-di-tert-butylphenyl)phosphite; hydrogen / toluene / 20 h / 100 °C / 37503.8 Torr / Inert atmosphere

4.1: toluene-4-sulfonic acid / 5,5-dimethyl-1,3-cyclohexadiene / 1.5 h / 130 °C / Inert atmosphere

5.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C

6.1: dichloromethane / 4.5 h / 0 - 20 °C

With oxalyl dichloride; dicarbonylacetylacetonato rhodium (I); tris(2,4-di-tert-butylphenyl)phosphite; hydrogen; tetrabutylammonium acetate; palladium diacetate; toluene-4-sulfonic acid; N,N-dimethyl-formamide; In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; toluene;

Reference yield:

: tert-butyl 4-[5-(3,5-dichlorophenyl)-2-hydroxy-5-(trifluoromethyl)tetrahydrofuran-3-yl]-2-methylbenzoate

: 1425943-24-3
4-[(2R)-2-(3,5-dichlorophenyl)-2-(trifiuoromethyl)-3H-furan-4-yl]-N-(1,1-dioxothietan-3-yl)-2-methylbenzamide

: 1425943-23-2
4-[(2S)-2-(3,5-dichloro-phenyl)-2-trifluoromethyl-3H-furan-4-yl]-N-(1,1-dioxo-1λ⁶-thietan-3-yl)-2-methyl-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / 5,5-dimethyl-1,3-cyclohexadiene / 1.5 h / 130 °C / Inert atmosphere

2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C

3: dichloromethane / 4.5 h / 0 - 20 °C

With oxalyl dichloride; toluene-4-sulfonic acid; N,N-dimethyl-formamide; In 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane;