[4-({[(5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy}methyl)phenyl]acetic acid

Base Information

Chemical Name:[4-({[(5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy}methyl)phenyl]acetic acid
CAS No.:1456814-36-0
Molecular Formula:C₂₄H₃₂O₇
Molecular Weight:432.514
Hs Code.:

Synonyms:[4-({[(5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy}methyl)phenyl]acetic acid

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Chemical Property of [4-({[(5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy}methyl)phenyl]acetic acid

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Technology Process of [4-({[(5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy}methyl)phenyl]acetic acid

There total 3 articles about [4-({[(5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy}methyl)phenyl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1456814-33-7
methyl [4-({[(5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino-[4,3-i]isochromen-10-yl]oxy}methyl)phenyl]acetate

: 1456814-36-0
[4-({[(5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy}methyl)phenyl]acetic acid

Guidance literature:: With potassium hydroxide; In methanol; water; at 20 ℃; for 96h; Inert atmosphere;
DOI:10.1002/cmdc.201200536

Reference yield:

: 73401-74-8
4-hydroxymethylphenylacetic acid

: 1456814-36-0
[4-({[(5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy}methyl)phenyl]acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid / 3 h / Reflux; Inert atmosphere

2.1: trimethylsilyl trifluoromethanesulfonate; Ag*ClO₄^(1-)=AgClO₄^(1-) / diethyl ether / 3 h / -78 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: potassium hydroxide / methanol; water / 96 h / 20 °C / Inert atmosphere

With Ag*ClO₄^(1-)=AgClO₄^(1-); trimethylsilyl trifluoromethanesulfonate; sulfuric acid; potassium hydroxide; In methanol; diethyl ether; water;
DOI:10.1002/cmdc.201200536

Reference yield:

: 155380-11-3
methyl 4-(hydroxymethyl)phenylacetate

: 1456814-36-0
[4-({[(5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy}methyl)phenyl]acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: trimethylsilyl trifluoromethanesulfonate; Ag*ClO₄^(1-)=AgClO₄^(1-) / diethyl ether / 3 h / -78 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: potassium hydroxide / methanol; water / 96 h / 20 °C / Inert atmosphere

With Ag*ClO₄^(1-)=AgClO₄^(1-); trimethylsilyl trifluoromethanesulfonate; potassium hydroxide; In methanol; diethyl ether; water;
DOI:10.1002/cmdc.201200536