N-[3-(dimethylamino)propyl]-1-methyl-4-({[1-methyl-4-({[1-methyl-4-({[4-({[(5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy}methyl)phenyl]acetyl}amino)-1H-pyrrol-2-yl]carbonyl}amino)-1H-pyrrol-2-yl]carbonyl}amino)-1H-pyrrole-2-carboxamide

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Chemical Name:N-[3-(dimethylamino)propyl]-1-methyl-4-({[1-methyl-4-({[1-methyl-4-({[4-({[(5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy}methyl)phenyl]acetyl}amino)-1H-pyrrol-2-yl]carbonyl}amino)-1H-pyrrol-2-yl]carbonyl}amino)-1H-pyrrole-2-carboxamide
CAS No.:1456814-29-1
Molecular Formula:C₄₇H₆₂N₈O₉
Molecular Weight:883.057
Hs Code.:

N-[3-(dimethylamino)propyl]-1-methyl-4-({[1-methyl-4-({[1-methyl-4-({[4-({[(5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy}methyl)phenyl]acetyl}amino)-1H-pyrrol-2-yl]carbonyl}amino)-1H-pyrrol-2-yl]carbonyl}amino)-1H-pyrrole-2-carboxamide

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Suppliers and Price of N-[3-(dimethylamino)propyl]-1-methyl-4-({[1-methyl-4-({[1-methyl-4-({[4-({[(5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy}methyl)phenyl]acetyl}amino)-1H-pyrrol-2-yl]carbonyl}amino)-1H-pyrrol-2-yl]carbonyl}amino)-1H-pyrrole-2-carboxamide

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Chemical Property of N-[3-(dimethylamino)propyl]-1-methyl-4-({[1-methyl-4-({[1-methyl-4-({[4-({[(5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy}methyl)phenyl]acetyl}amino)-1H-pyrrol-2-yl]carbonyl}amino)-1H-pyrrol-2-yl]carbonyl}amino)-1H-pyrrole-2-carboxamide

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Technology Process of N-[3-(dimethylamino)propyl]-1-methyl-4-({[1-methyl-4-({[1-methyl-4-({[4-({[(5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy}methyl)phenyl]acetyl}amino)-1H-pyrrol-2-yl]carbonyl}amino)-1H-pyrrol-2-yl]carbonyl}amino)-1H-pyrrole-2-carboxamide

There total 4 articles about N-[3-(dimethylamino)propyl]-1-methyl-4-({[1-methyl-4-({[1-methyl-4-({[4-({[(5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy}methyl)phenyl]acetyl}amino)-1H-pyrrol-2-yl]carbonyl}amino)-1H-pyrrol-2-yl]carbonyl}amino)-1H-pyrrole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 1456814-36-0
[4-({[(5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy}methyl)phenyl]acetic acid

: 78486-18-7
3-(1-methyl-4-(1-methyl-4-(1-methyl-4-aminopyrrole-2-carboxamido)pyrrole-2-carboxamido)pyrrole-2-carboxamido)dimethylaminopropane

: 1456814-29-1
N-[3-(dimethylamino)propyl]-1-methyl-4-({[1-methyl-4-({[1-methyl-4-({[4-({[(5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy}methyl)phenyl]acetyl}amino)-1H-pyrrol-2-yl]carbonyl}amino)-1H-pyrrol-2-yl]carbonyl}amino)-1H-pyrrole-2-carboxamide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 ℃; Inert atmosphere;
DOI:10.1002/cmdc.201200536

Reference yield:

: 73401-74-8
4-hydroxymethylphenylacetic acid

: 1456814-29-1
N-[3-(dimethylamino)propyl]-1-methyl-4-({[1-methyl-4-({[1-methyl-4-({[4-({[(5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy}methyl)phenyl]acetyl}amino)-1H-pyrrol-2-yl]carbonyl}amino)-1H-pyrrol-2-yl]carbonyl}amino)-1H-pyrrole-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / 3 h / Reflux; Inert atmosphere

2.1: trimethylsilyl trifluoromethanesulfonate; Ag*ClO₄^(1-)=AgClO₄^(1-) / diethyl ether / 3 h / -78 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: potassium hydroxide / methanol; water / 96 h / 20 °C / Inert atmosphere

4.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 °C / Inert atmosphere

With Ag*ClO₄^(1-)=AgClO₄^(1-); trimethylsilyl trifluoromethanesulfonate; sulfuric acid; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In methanol; diethyl ether; water; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201200536

Reference yield:

: 1456814-33-7
methyl [4-({[(5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino-[4,3-i]isochromen-10-yl]oxy}methyl)phenyl]acetate

: 1456814-29-1
N-[3-(dimethylamino)propyl]-1-methyl-4-({[1-methyl-4-({[1-methyl-4-({[4-({[(5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy}methyl)phenyl]acetyl}amino)-1H-pyrrol-2-yl]carbonyl}amino)-1H-pyrrol-2-yl]carbonyl}amino)-1H-pyrrole-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / methanol; water / 96 h / 20 °C / Inert atmosphere

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 °C / Inert atmosphere

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201200536