methyl 2-(4-chlorophenyl)-1-tosyl-2,5-dihydro-1H-pyrrole-3-carboxylate

Base Information

• Chemical Name: methyl 2-(4-chlorophenyl)-1-tosyl-2,5-dihydro-1H-pyrrole-3-carboxylate
• CAS No.: 190272-46-9
• Molecular Formula: C₁₉H₁₈ClNO₄S
• Molecular Weight: 391.875

Synonyms:methyl 2-(4-chlorophenyl)-1-tosyl-2,5-dihydro-1H-pyrrole-3-carboxylate

Chemical Property of methyl 2-(4-chlorophenyl)-1-tosyl-2,5-dihydro-1H-pyrrole-3-carboxylate

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Technology Process of methyl 2-(4-chlorophenyl)-1-tosyl-2,5-dihydro-1H-pyrrole-3-carboxylate

There total 5 articles about methyl 2-(4-chlorophenyl)-1-tosyl-2,5-dihydro-1H-pyrrole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methyl buta-2,3-dienoate (18913-35-4) + N-(4-chlorobenzylidene)-4-methylbenzenesulfonamide (357417-22-2) → methyl 2-(4-chlorophenyl)-1-tosyl-2,5-dihydro-1H-pyrrole-3-carboxylate (190272-46-9)

Guidance literature:

triphenylphosphine; In benzene; Ambient temperature;

DOI:10.1016/S0040-4039(97)00656-4

Reference yield: 68.0%

methyl-2-{[(N-allyl-4-methylphenyl)sulfonamido](4-chlorophenyl)methyl}acrylate → methyl 2-(4-chlorophenyl)-1-tosyl-2,5-dihydro-1H-pyrrole-3-carboxylate (190272-46-9)

Guidance literature:

With C₅₄H₆₉Cl₂N₂PRu; carbonic acid dimethyl ester; at 120 ℃; for 0.0166667h; Flow reactor; Green chemistry;

DOI:10.1039/c7gc00235a

Reference yield:

N-(4-chlorobenzylidene)-4-methylbenzenesulfonamide (357417-22-2) + Methyl 2-butynoate (23326-27-4) → methyl 2-(4-chlorophenyl)-1-tosyl-2,5-dihydro-1H-pyrrole-3-carboxylate (190272-46-9) + (2R,5R)-2-(4-Chloro-phenyl)-5-[(4-chloro-phenyl)-(toluene-4-sulfonylamino)-methyl]-1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrole-3-carboxylic acid methyl ester

Guidance literature:

With tributylphosphine; In benzene; Yield given. Yields of byproduct given; Ambient temperature;

DOI:10.1021/jo9723063

upstream raw materials:

methyl buta-2,3-dienoate

N-(4-chlorobenzylidene)-4-methylbenzenesulfonamide

Methyl 2-butynoate

toluene-4-sulfonamide

Downstream raw materials:

2-(4-Chloro-phenyl)-1-(toluene-4-sulfonyl)-1H-pyrrole-3-carboxylic acid methyl ester

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