Naltalimide

Base Information

Chemical Name:Naltalimide
CAS No.:160359-68-2
Molecular Formula:C₂₈H₂₈N₂O₅
Molecular Weight:472.541
Hs Code.:
UNII:PUO0LMS4NX
DSSTox Substance ID:DTXSID10166868
NCI Thesaurus Code:C174856
Wikidata:Q19598101
Wikipedia:Naltalimide

Synonyms:N-(17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-yl)phthalimide;naltalimide;TRK-130

Suppliers and Price of Naltalimide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 0 raw suppliers

Chemical Property of Naltalimide

Chemical Property:

XLogP3:1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:472.19982200
Heavy Atom Count:35
Complexity:930

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CC1CN2CCC34C5C(CCC3(C2CC6=C4C(=C(C=C6)O)O5)O)N7C(=O)C8=CC=CC=C8C7=O
Isomeric SMILES:C1C[C@]2([C@H]3CC4=C5[C@@]2(CCN3CC6CC6)[C@H]([C@@H]1N7C(=O)C8=CC=CC=C8C7=O)OC5=C(C=C4)O)O

Technology Process of Naltalimide

There total 1 articles about Naltalimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 85-44-9
phthalic anhydride

: 67025-97-2
6β-naltrexamine

: 160359-68-2
Naltalimide

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 140 ℃; for 4h;

Reference yield: 85.0%

: 100-39-0
benzyl bromide

: 160359-68-2
Naltalimide

: 2-((4R,4aS,7R,7aR,12bS)-9-(benzyloxy)-3-(cyclopropylmethyl)-4a-hydroxy-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl)isoindoline-1,3-dione

Guidance literature:: benzyl bromide; Naltalimide; With potassium carbonate; In N,N-dimethyl-formamide; at 40 ℃; for 25h;

With hydrogenchloride; In tetrahydrofuran; water; ethyl acetate;

With sodium hydrogencarbonate; In water; pH=8;

Reference yield:

: 160359-68-2
Naltalimide

: (E)-3-(4-chlorophenyl)-N-((4R,4aS,7R,7aR,12bS,13S)-3-(cyclopropylmethyl)-4a,9,13-trihydroxy-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl)-N-methylacrylamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

2.1: ammonium hexanitratocerate / acetonitrile / 4 h / 0 - 20 °C

3.1: hydrazine / ethanol / 3 h / 70 °C

4.1: 4 h / 20 °C

4.2: 0.58 h / 20 °C

5.1: hydrogenchloride; palladium on activated charcoal; hydrogen / methanol / 9 h / 20 °C

6.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 17 h / 20 °C

With hydrogenchloride; palladium on activated charcoal; ammonium hexanitratocerate; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; hydrazine; In methanol; ethanol; N,N-dimethyl-formamide; acetonitrile;