trans-(E)-6-<2-(2,4-dichlorophenyl)ethenyl>-3,4,5,6-tetrahydro-4-hydroxy-4-methyl-2H-pyran-2-one

Base Information

Chemical Name:trans-(E)-6-<2-(2,4-dichlorophenyl)ethenyl>-3,4,5,6-tetrahydro-4-hydroxy-4-methyl-2H-pyran-2-one
CAS No.:93863-48-0
Molecular Formula:C₁₄H₁₄Cl₂O₃
Molecular Weight:301.169
Hs Code.:

Synonyms:trans-(E)-6-<2-(2,4-dichlorophenyl)ethenyl>-3,4,5,6-tetrahydro-4-hydroxy-4-methyl-2H-pyran-2-one

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Chemical Property of trans-(E)-6-<2-(2,4-dichlorophenyl)ethenyl>-3,4,5,6-tetrahydro-4-hydroxy-4-methyl-2H-pyran-2-one

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Technology Process of trans-(E)-6-<2-(2,4-dichlorophenyl)ethenyl>-3,4,5,6-tetrahydro-4-hydroxy-4-methyl-2H-pyran-2-one

There total 5 articles about trans-(E)-6-<2-(2,4-dichlorophenyl)ethenyl>-3,4,5,6-tetrahydro-4-hydroxy-4-methyl-2H-pyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.4%

: 93863-47-9
6-(2,4-dichlorphenyl)-2-oxo-5-hexen-4-yl 2-bromoacetate

: 93863-48-0
trans-(E)-6-<2-(2,4-dichlorophenyl)ethenyl>-3,4,5,6-tetrahydro-4-hydroxy-4-methyl-2H-pyran-2-one

: 93863-49-1
cis-(E)-6-<2-(2,4-dichlorophenyl)ethenyl>-3,4,5,6-tetrahydro-4-hydroxy-4-methyl-2H-pyran-2-one

Guidance literature:: With diethylaluminium chloride; copper(I) bromide; zinc; In tetrahydrofuran; toluene; for 5h;
DOI:10.1021/jm00381a014

Reference yield:

: 874-42-0
2,4-dichlorobenzaldeyhde

: 93863-48-0
trans-(E)-6-<2-(2,4-dichlorophenyl)ethenyl>-3,4,5,6-tetrahydro-4-hydroxy-4-methyl-2H-pyran-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaOH, 2.) Ac₂O, 3.)aq. HCl

2: 1.) tri-n-butyltin methoxide / 1.) 60-79 deg C, 1 h, 2.) 70 deg C, 4 h

3: 87 percent / pyridine / 2 h / 20 °C

4: 75 percent / Zn, CuBr, Et₂AlCl / tetrahydrofuran; toluene / 5 h

5: 1.) 1 N aq. NaOH / 1.) EtOH, RT, 1 h, 2.) toluene, reflux, 6 h

With pyridine; hydrogenchloride; sodium hydroxide; tributyltin methoxide; diethylaluminium chloride; acetic anhydride; copper(I) bromide; zinc; In tetrahydrofuran; toluene;
DOI:10.1021/jm00381a014

Reference yield:

: 70017-27-5
3-(2,4-Dichlorophenyl)propenal

: 93863-48-0
trans-(E)-6-<2-(2,4-dichlorophenyl)ethenyl>-3,4,5,6-tetrahydro-4-hydroxy-4-methyl-2H-pyran-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) tri-n-butyltin methoxide / 1.) 60-79 deg C, 1 h, 2.) 70 deg C, 4 h

2: 87 percent / pyridine / 2 h / 20 °C

3: 75 percent / Zn, CuBr, Et₂AlCl / tetrahydrofuran; toluene / 5 h

4: 1.) 1 N aq. NaOH / 1.) EtOH, RT, 1 h, 2.) toluene, reflux, 6 h

With pyridine; sodium hydroxide; tributyltin methoxide; diethylaluminium chloride; copper(I) bromide; zinc; In tetrahydrofuran; toluene;
DOI:10.1021/jm00381a014