4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-oxopentanoic acid (1R,2S)-2-phenylcyclohexyl ester

Base Information

Chemical Name:4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-oxopentanoic acid (1R,2S)-2-phenylcyclohexyl ester
CAS No.:851314-93-7
Molecular Formula:C₂₅H₂₉FO₄
Molecular Weight:412.501
Hs Code.:

Synonyms:4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-oxopentanoic acid (1R,2S)-2-phenylcyclohexyl ester

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Chemical Property of 4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-oxopentanoic acid (1R,2S)-2-phenylcyclohexyl ester

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Technology Process of 4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-oxopentanoic acid (1R,2S)-2-phenylcyclohexyl ester

There total 4 articles about 4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-oxopentanoic acid (1R,2S)-2-phenylcyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 217196-31-1
4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-oxopentanoic acid

: 98919-68-7
(1R,2S)-trans-2-phenylcyclohexanol

: 851314-93-7
4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-oxopentanoic acid (1R,2S)-2-phenylcyclohexyl ester

Guidance literature:: With toluene-4-sulfonic acid; In water; toluene; at 110 ℃; for 3h;
DOI:10.1021/jo061839l

Reference yield:

: 566920-34-1
4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-oxopentanoic acid ethyl ester

: 851314-93-7
4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-oxopentanoic acid (1R,2S)-2-phenylcyclohexyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 94 g / NaOH / tetrahydrofuran; H₂O / cooling

2: 96 percent / TsOH / toluene; H₂O / 3 h / 110 °C

With sodium hydroxide; toluene-4-sulfonic acid; In tetrahydrofuran; water; toluene;
DOI:10.1021/jo061839l

Reference yield:

: 851314-92-6
2-(2-chloro-1,1-dimethylethyl)-4-fluoro-1-methoxybenzene

: 851314-93-7
4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-oxopentanoic acid (1R,2S)-2-phenylcyclohexyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: magnesium; 1,2-dibromoethane / diethyl ether / 16 h

1.2: diethyl ether / 6 h / -60 °C

2.1: 94 g / NaOH / tetrahydrofuran; H₂O / cooling

3.1: 96 percent / TsOH / toluene; H₂O / 3 h / 110 °C

With sodium hydroxide; toluene-4-sulfonic acid; magnesium; ethylene dibromide; In tetrahydrofuran; diethyl ether; water; toluene; 1.2: Grignard reaction;
DOI:10.1021/jo061839l