1,2-bis(iodoethynyl)-4,5-dimethoxybenzene

Base Information

• Chemical Name: 1,2-bis(iodoethynyl)-4,5-dimethoxybenzene
• CAS No.: 1359167-14-8
• Molecular Formula: C₁₂H₈I₂O₂
• Molecular Weight: 438.003
• Mol file: 1359167-14-8.mol

Synonyms:1,2-bis(iodoethynyl)-4,5-dimethoxybenzene

Chemical Property of 1,2-bis(iodoethynyl)-4,5-dimethoxybenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2-bis(iodoethynyl)-4,5-dimethoxybenzene

There total 4 articles about 1,2-bis(iodoethynyl)-4,5-dimethoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1,2-diethynyl-4,5-dimethoxybenzene (170160-98-2) → 1,2-bis(iodoethynyl)-4,5-dimethoxybenzene (1359167-14-8)

Guidance literature:

With N-iodo-succinimide; silver nitrate; In water; acetone; at 20 ℃; for 3h; Darkness;

DOI:10.1142/S1088424611003781

Reference yield: 60.0%

((4,5-dimethoxy-1,2-phenylene)bis(ethyne-2,1-diyl))bis(trimethylsilane) (803733-65-5) → 1,2-bis(iodoethynyl)-4,5-dimethoxybenzene (1359167-14-8)

Guidance literature:

With N-iodo-succinimide; silver fluoride; In acetonitrile; at 23 ℃; for 18h; Inert atmosphere; Darkness;

DOI:10.1021/ol502099j

Reference yield:

1,2-diiodo-4,5-dimethoxybenzene (110190-08-4) → 1,2-bis(iodoethynyl)-4,5-dimethoxybenzene (1359167-14-8)

Guidance literature:

Multi-step reaction with 3 steps

1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / tetrahydrofuran / 55 h / 60 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 22 h / 20 °C

3: N-iodo-succinimide; silver nitrate / water; acetone / 3 h / 20 °C / Darkness

With N-iodo-succinimide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; silver nitrate; triethylamine; In tetrahydrofuran; water; acetone; 1: Sonogashira coupling;

DOI:10.1142/S1088424611003781

upstream raw materials:

1,2-diiodo-4,5-dimethoxybenzene

1,2-diethynyl-4,5-dimethoxybenzene

((4,5-dimethoxy-1,2-phenylene)bis(ethyne-2,1-diyl))bis(trimethylsilane)

1,2-dimethoxybenzene

Downstream raw materials:

4,4'-(4,5-dimethoxy-1,2-phenylene)bis(5-iodo-1-(3-(triisopropylsilyl)prop-2-yn-1-yl)-1H-1,2,3-triazole)