N,N-bis(tert-butoxycarbonyl)-5-(5-(tert-butoxycarbonyl)-4,5,6,7-tetrahydrothieno[3, 2-c]pyridin-2-yl)-3-(1-(5-chloro-2-(trifluoromethyl)phenyl)ethoxy)pyridin-2-amine

Base Information

Chemical Name:N,N-bis(tert-butoxycarbonyl)-5-(5-(tert-butoxycarbonyl)-4,5,6,7-tetrahydrothieno[3, 2-c]pyridin-2-yl)-3-(1-(5-chloro-2-(trifluoromethyl)phenyl)ethoxy)pyridin-2-amine
CAS No.:1613148-52-9
Molecular Formula:C₃₆H₄₃ClF₃N₃O₇S
Molecular Weight:754.268
Hs Code.:

N,N-bis(tert-butoxycarbonyl)-5-(5-(tert-butoxycarbonyl)-4,5,6,7-tetrahydrothieno[3, 2-c]pyridin-2-yl)-3-(1-(5-chloro-2-(trifluoromethyl)phenyl)ethoxy)pyridin-2-amine

Synonyms:N,N-bis(tert-butoxycarbonyl)-5-(5-(tert-butoxycarbonyl)-4,5,6,7-tetrahydrothieno[3, 2-c]pyridin-2-yl)-3-(1-(5-chloro-2-(trifluoromethyl)phenyl)ethoxy)pyridin-2-amine

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Chemical Property of N,N-bis(tert-butoxycarbonyl)-5-(5-(tert-butoxycarbonyl)-4,5,6,7-tetrahydrothieno[3, 2-c]pyridin-2-yl)-3-(1-(5-chloro-2-(trifluoromethyl)phenyl)ethoxy)pyridin-2-amine

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Technology Process of N,N-bis(tert-butoxycarbonyl)-5-(5-(tert-butoxycarbonyl)-4,5,6,7-tetrahydrothieno[3, 2-c]pyridin-2-yl)-3-(1-(5-chloro-2-(trifluoromethyl)phenyl)ethoxy)pyridin-2-amine

There total 7 articles about N,N-bis(tert-butoxycarbonyl)-5-(5-(tert-butoxycarbonyl)-4,5,6,7-tetrahydrothieno[3, 2-c]pyridin-2-yl)-3-(1-(5-chloro-2-(trifluoromethyl)phenyl)ethoxy)pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 949922-62-7
2-bromo-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylic acid tert-butyl ester

: 1613148-51-8
N,N-bis(tert-butoxycarbonyl)-3-(1-(5-chloro-2-(trifluoromethyl)phenyl)ethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine

: 1613148-52-9
N,N-bis(tert-butoxycarbonyl)-5-(5-(tert-butoxycarbonyl)-4,5,6,7-tetrahydrothieno[3, 2-c]pyridin-2-yl)-3-(1-(5-chloro-2-(trifluoromethyl)phenyl)ethoxy)pyridin-2-amine

Guidance literature:: 2-bromo-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylic acid tert-butyl ester; With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; In 1,4-dioxane; water; at 90 ℃; for 0.5h; Inert atmosphere;

N,N-bis(tert-butoxycarbonyl)-3-(1-(5-chloro-2-(trifluoromethyl)phenyl)ethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine; In 1,4-dioxane; water; at 110 ℃;

Reference yield:

: 54231-35-5
3-fuoro-2-nitropyridine

: 1613148-52-9
N,N-bis(tert-butoxycarbonyl)-5-(5-(tert-butoxycarbonyl)-4,5,6,7-tetrahydrothieno[3, 2-c]pyridin-2-yl)-3-(1-(5-chloro-2-(trifluoromethyl)phenyl)ethoxy)pyridin-2-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0 °C

2.1: hydrogenchloride; iron / 2.5 h / 100 °C

3.1: N-Bromosuccinimide / acetonitrile / 1 h / 0 °C

4.1: dmap / N,N-dimethyl-formamide / 20 °C

5.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 2.5 h / 80 °C / Inert atmosphere

6.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / water; 1,4-dioxane / 0.5 h / 90 °C / Inert atmosphere

6.2: 110 °C

With hydrogenchloride; dmap; N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; iron; sodium hydride; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 1613148-47-2
3-(1-(5-chloro-2-(trifluoromethyl)phenyl)ethoxy)-2-nitropyridine

: 1613148-52-9
N,N-bis(tert-butoxycarbonyl)-5-(5-(tert-butoxycarbonyl)-4,5,6,7-tetrahydrothieno[3, 2-c]pyridin-2-yl)-3-(1-(5-chloro-2-(trifluoromethyl)phenyl)ethoxy)pyridin-2-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride; iron / 2.5 h / 100 °C

2.1: N-Bromosuccinimide / acetonitrile / 1 h / 0 °C

3.1: dmap / N,N-dimethyl-formamide / 20 °C

4.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 2.5 h / 80 °C / Inert atmosphere

5.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / water; 1,4-dioxane / 0.5 h / 90 °C / Inert atmosphere

5.2: 110 °C

With hydrogenchloride; dmap; N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; iron; caesium carbonate; In 1,4-dioxane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;