Technology Process of methyl (6S,9S,12S)-12-{[(benzyloxy)carbonyl]amino}-9-(2-methylpropyl)-8,11-dioxo-1,7,10,15-tetraazabicyclo[12.2.1]heptadeca-14(17),15-diene-6-carboxylate
There total 5 articles about methyl (6S,9S,12S)-12-{[(benzyloxy)carbonyl]amino}-9-(2-methylpropyl)-8,11-dioxo-1,7,10,15-tetraazabicyclo[12.2.1]heptadeca-14(17),15-diene-6-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;
In
N,N-dimethyl-formamide;
at 20 ℃;
Inert atmosphere;
DOI:10.1002/cbdv.201200320
- Guidance literature:
-
Multi-step reaction with 2 steps
1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C / Inert atmosphere
2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
With
N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/cbdv.201200320
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
2.1: sodium hydride / N,N-dimethyl-formamide; hexane / 0.5 h / -15 °C / Inert atmosphere
2.2: 4 h / -15 - -5 °C / Inert atmosphere
3.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C / Inert atmosphere
4.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
With
1-hydroxy-7-aza-benzotriazole; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;
In
hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/cbdv.201200320
