(5R,6R,7S,8S)-6,7,8-tris(benzyloxy)-5-[(benzyloxy)-methyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine

Base Information

Chemical Name:(5R,6R,7S,8S)-6,7,8-tris(benzyloxy)-5-[(benzyloxy)-methyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine
CAS No.:191863-33-9
Molecular Formula:C₃₆H₃₆N₂O₄
Molecular Weight:560.693
Hs Code.:

Synonyms:(5R,6R,7S,8S)-6,7,8-tris(benzyloxy)-5-[(benzyloxy)-methyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine

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Chemical Property of (5R,6R,7S,8S)-6,7,8-tris(benzyloxy)-5-[(benzyloxy)-methyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine

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Technology Process of (5R,6R,7S,8S)-6,7,8-tris(benzyloxy)-5-[(benzyloxy)-methyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine

There total 18 articles about (5R,6R,7S,8S)-6,7,8-tris(benzyloxy)-5-[(benzyloxy)-methyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 536-74-3
phenylacetylene

: 244138-64-5
(5R,6R,7S,8S)-6,7,8-tris(benzyloxy)-5-[(benzyloxy)methyl]-2-iodo-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine

: 191863-33-9
(5R,6R,7S,8S)-6,7,8-tris(benzyloxy)-5-[(benzyloxy)-methyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine

: 263720-36-1
(5R,6R,7S,8S)-6,7,8-tris(benzyloxy)-5-[(benzyloxy)methyl]-2-(2-phenylethynyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In N,N-dimethyl-formamide; at 80 ℃; for 2h;
DOI:10.1002/(SICI)1522-2675(20000119)83:1<58::AID-HLCA58>3.0.CO;2-K

Reference yield: 71.0%

: 762-04-9
phosphonic acid diethyl ester

: 244138-64-5
(5R,6R,7S,8S)-6,7,8-tris(benzyloxy)-5-[(benzyloxy)methyl]-2-iodo-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine

: 191863-33-9
(5R,6R,7S,8S)-6,7,8-tris(benzyloxy)-5-[(benzyloxy)-methyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine

: 244138-65-6
diethyl (5R,6R,7S,8S)-6,7,8-tris(benzyloxy)-5-[(benzyloxy)methyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-2-phosphonate

Guidance literature:: With 1,2,2,6,6-pentamethylpiperidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 95 ℃; for 19.5h;
DOI:10.1002/(SICI)1522-2675(19990804)82:8<1137::AID-HLCA1137>3.0.CO;2-N

Reference yield: 64.0%

: 108-88-3,15644-74-3,16713-13-6
toluene

: 263720-01-0
(5R,6R,7S,8S)-6,7,8-tris(benzyloxy)-5-[(benzyloxy)methyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-2-carbaldehyde

: 191863-33-9
(5R,6R,7S,8S)-6,7,8-tris(benzyloxy)-5-[(benzyloxy)-methyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine

: 2-phenyl-1-[(5R,6R,7S,8S)-6,7,8-tris(benzyloxy)-5-[(benzyloxy)methyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl]ethanol

Guidance literature:: toluene; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In hexane; at -78 - 23 ℃;

(5R,6R,7S,8S)-6,7,8-tris(benzyloxy)-5-[(benzyloxy)methyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-2-carbaldehyde; In tetrahydrofuran; at -78 - 23 ℃; for 1h;
DOI:10.1002/(SICI)1522-2675(20000119)83:1<58::AID-HLCA58>3.0.CO;2-K