1-[2-(trimethylsilylethynyl)phenyl]-2-[4-(triisopropylsilylethynyl)pyridin-3-yl]ethyne

Base Information

Chemical Name:1-[2-(trimethylsilylethynyl)phenyl]-2-[4-(triisopropylsilylethynyl)pyridin-3-yl]ethyne
CAS No.:860021-99-4
Molecular Formula:C₂₉H₃₇NSi₂
Molecular Weight:455.79
Hs Code.:

Synonyms:1-[2-(trimethylsilylethynyl)phenyl]-2-[4-(triisopropylsilylethynyl)pyridin-3-yl]ethyne

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Chemical Property of 1-[2-(trimethylsilylethynyl)phenyl]-2-[4-(triisopropylsilylethynyl)pyridin-3-yl]ethyne

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Technology Process of 1-[2-(trimethylsilylethynyl)phenyl]-2-[4-(triisopropylsilylethynyl)pyridin-3-yl]ethyne

There total 6 articles about 1-[2-(trimethylsilylethynyl)phenyl]-2-[4-(triisopropylsilylethynyl)pyridin-3-yl]ethyne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 860021-85-8
3-ethynyl-4-triisopropylsilylethynylpyridine

: 137648-47-6
1-iodo-2-ethynylbenzene

: 860021-99-4
1-[2-(trimethylsilylethynyl)phenyl]-2-[4-(triisopropylsilylethynyl)pyridin-3-yl]ethyne

Guidance literature:: With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In toluene; at 20 ℃; for 144h;
DOI:10.1021/jo040276f

Reference yield:

: 860021-82-5
3-bromo-4-(triisopropylsilylethynyl)pyridine

: 860021-99-4
1-[2-(trimethylsilylethynyl)phenyl]-2-[4-(triisopropylsilylethynyl)pyridin-3-yl]ethyne

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-BuLi / hexane; diethyl ether / 1.5 h / -78 °C

1.2: 80 percent / 1,2-diiodoethane / hexane; diethyl ether / 3 h / -78 °C

2.1: 96 percent / CuI; triethylamine; PdCl₂(PPh₃)2 / 20 °C

3.1: 99 percent / K₂CO₃ / methanol / 20 h / 20 °C

4.1: 77 percent / CuI; triethylamine / PdCl₂(PPh₃)2 / toluene / 144 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; n-butyllithium; potassium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In methanol; diethyl ether; hexane; toluene; 2.1: Sonogashira reaction / 4.1: Sonogashira coupling;
DOI:10.1021/jo040276f

Reference yield:

: 860021-83-6
3-iodo-4-(triisopropylsilylethynyl)pyridine

: 860021-99-4
1-[2-(trimethylsilylethynyl)phenyl]-2-[4-(triisopropylsilylethynyl)pyridin-3-yl]ethyne

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / CuI; triethylamine; PdCl₂(PPh₃)2 / 20 °C

2: 99 percent / K₂CO₃ / methanol / 20 h / 20 °C

3: 77 percent / CuI; triethylamine / PdCl₂(PPh₃)2 / toluene / 144 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In methanol; toluene; 1: Sonogashira reaction / 3: Sonogashira coupling;
DOI:10.1021/jo040276f