3-ETHOXYCARBONYL-1-PHENYLPENTANE-1,4-DIONE

Base Information

• Chemical Name: 3-ETHOXYCARBONYL-1-PHENYLPENTANE-1,4-DIONE
• CAS No.: 52313-46-9
• Molecular Formula: C14H16 O4
• Molecular Weight: 248.279
• Hs Code.: 2918300090
• Mol file: 52313-46-9.mol

Synonyms:Ethyl2-acetyl-4-oxo-4-phenylbutanoate; Ethyl 2-acetyl-4-oxo-4-phenylbutyrate; NSC225097

Chemical Property of 3-ETHOXYCARBONYL-1-PHENYLPENTANE-1,4-DIONE

Chemical Property:

• Vapor Pressure: 2.36E-06mmHg at 25°C
• Boiling Point: 392°Cat760mmHg
• Flash Point: 173.8°C
• PSA: 60.44000
• Density: 1.123g/cm³
• LogP: 2.02770

Purity/Quality:

99% ^*data from raw suppliers

3-Oxo-2-(2-oxo-2-phenyl-ethyl)-butyricacidethylester 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-ETHOXYCARBONYL-1-PHENYLPENTANE-1,4-DIONE

There total 9 articles about 3-ETHOXYCARBONYL-1-PHENYLPENTANE-1,4-DIONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl acetoacetate (141-97-9) + α-bromoacetophenone (70-11-1) → ethyl 2-acetyl-4-oxo-4-phenylbutanoate (52313-46-9)

Guidance literature:

α-bromoacetophenone; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.5h; Inert atmosphere;

ethyl acetoacetate; In tetrahydrofuran; at 20 ℃; for 4h;

Reference yield: 80.0%

enolate sodique de l'acetylacetate d'ethyle (20412-62-8,66279-49-0) + α-bromoacetophenone (70-11-1) → ethyl 2-acetyl-4-oxo-4-phenylbutanoate (52313-46-9)

Guidance literature:

In toluene; for 24h;

Reference yield: 25.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + ethyl acetoacetate (141-97-9) → ethyl 2-acetyl-4-oxo-4-phenylbutanoate (52313-46-9) + 2-acetyl-4-oxo-2-phenacyl-4-phenyl-butyric acid ethyl ester

Guidance literature:

With copper(l) chloride; In dimethyl sulfoxide; at 60 ℃; for 2h;

DOI:10.1039/c6cc01942k

upstream raw materials:

sodium ethyl acetylacetate enolate

α-bromoacetophenone

ethyl acetoacetate

enolate sodique de l'acetylacetate d'ethyle

Downstream raw materials:

1,5-diphenylpyrazole-3-carboxylic acid

3-phenyl-2-cyclopenten-1-one

succinylbenzene

ethyl 5-phenylisoxazole-3-carboxylate