2-acetyl-3,5-dimethoxy-6-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl benzoate

Base Information

Chemical Name:2-acetyl-3,5-dimethoxy-6-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl benzoate
CAS No.:916888-60-3
Molecular Formula:C₂₃H₂₅NO₅
Molecular Weight:395.455
Hs Code.:

Synonyms:2-acetyl-3,5-dimethoxy-6-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl benzoate

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Chemical Property of 2-acetyl-3,5-dimethoxy-6-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl benzoate

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Technology Process of 2-acetyl-3,5-dimethoxy-6-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl benzoate

There total 5 articles about 2-acetyl-3,5-dimethoxy-6-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 98-88-4
benzoyl chloride

: 190973-17-2
1-(3-(1,2,3,6-tetrahydro-1-methylpyridin-4-yl)-2-hydroxy-4,6-dimethoxyphenyl)ethanone

: 916888-60-3
2-acetyl-3,5-dimethoxy-6-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl benzoate

Guidance literature:: With pyridine; dmap; at 20 ℃; for 0.75h;
DOI:10.1016/j.bmc.2006.07.060

Reference yield:

: 113225-07-3
1-methyl-4-(2,4,6-trimethoxyphenyl)-1,2,3,6-tetrahydropyridine

: 916888-60-3
2-acetyl-3,5-dimethoxy-6-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / BF₃*OEt₂ / CH₂Cl₂ / 20 °C

2: 75 percent / 4-(dimethylamino)pyridine; pyridine / 0.75 h / 20 °C

With pyridine; dmap; boron trifluoride diethyl etherate; In dichloromethane;
DOI:10.1016/j.bmc.2006.07.060

Reference yield:

: 1445-73-4
1-Methyl-4-piperidone

: 916888-60-3
2-acetyl-3,5-dimethoxy-6-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: HCl gas; AcOH

2: BF₃*Et₂O / CH₂Cl₂

3: pyridine

With pyridine; hydrogenchloride; boron trifluoride diethyl etherate; acetic acid; In dichloromethane; 1: Condensation / 2: Acylation / 3: Acylation;
DOI:10.1016/S0960-894X(00)00156-6