N¹-(4-chloro-3-fluorophenyl)-N²-((1R,2S)-2-(hydroxymethyl)-2,3-dihydro-1H-inden-1-yl)oxalamide

Base Information

• Chemical Name: N¹-(4-chloro-3-fluorophenyl)-N²-((1R,2S)-2-(hydroxymethyl)-2,3-dihydro-1H-inden-1-yl)oxalamide
• CAS No.: 1422851-50-0
• Molecular Formula: C₁₈H₁₆ClFN₂O₃
• Molecular Weight: 362.788

Synonyms:N¹-(4-chloro-3-fluorophenyl)-N²-((1R,2S)-2-(hydroxymethyl)-2,3-dihydro-1H-inden-1-yl)oxalamide

Chemical Property of N¹-(4-chloro-3-fluorophenyl)-N²-((1R,2S)-2-(hydroxymethyl)-2,3-dihydro-1H-inden-1-yl)oxalamide

Chemical Property:

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Technology Process of N¹-(4-chloro-3-fluorophenyl)-N²-((1R,2S)-2-(hydroxymethyl)-2,3-dihydro-1H-inden-1-yl)oxalamide

There total 16 articles about N¹-(4-chloro-3-fluorophenyl)-N²-((1R,2S)-2-(hydroxymethyl)-2,3-dihydro-1H-inden-1-yl)oxalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

C24H30ClFN2O3Si → N1-(4-chloro-3-fluorophenyl)-N2-((1R,2S)-2-(hydroxymethyl)-2,3-dihydro-1H-inden-1-yl)oxalamide (1422851-50-0)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

Reference yield:

(±)-N1-(4-chloro-3-fluorophenyl)-N2-(2-formylindan-1-yl)oxalamide → N1-(4-chloro-3-fluorophenyl)-N2-((1R,2S)-2-(hydroxymethyl)-2,3-dihydro-1H-inden-1-yl)oxalamide (1422851-50-0)

Guidance literature:

(±)-N¹-(4-chloro-3-fluorophenyl)-N²-(2-formylindan-1-yl)oxalamide; With 2,2,2-trifluoroacetic acid ammonia; In methanol; dichloromethane; at 20 ℃;

With sodium tetrahydroborate; ethanol;

Reference yield:

N1-(4-chloro-3-fluorophenyl)-N2-(2-formylindan-1-yl)oxalamide → N1-(4-chloro-3-fluorophenyl)-N2-((1R,2S)-2-(hydroxymethyl)-2,3-dihydro-1H-inden-1-yl)oxalamide (1422851-50-0)

Guidance literature:

N¹-(4-chloro-3-fluorophenyl)-N²-(2-formylindan-1-yl)oxalamide; With 2,2,2-trifluoroacetic acid ammonia; In methanol; dichloromethane; at 20 ℃; Inert atmosphere;

With sodium tris(acetoxy)borohydride; In ethanol; at 20 ℃; Inert atmosphere;

DOI:10.1021/ml300407y

upstream raw materials:

1-indene

ethyl 2-((4-chloro-3-fluorophenyl)amino)-2-oxoacetate

(1R,2R)-1-amino-2,3-dihydro-1H-indene-2-carboxylic acid

[(1R,2R)-1-amino-2,3-dihydro-1H-inden-2-yl] methanol

Downstream raw materials:

[(1R,2S)-1-{(2-((4-chloro-3-fluorophenyl)amino)-2-oxoacetamido)-2,3-dihydro-1H-inden-2-yl}methyl] methanesulfonate

N¹-((1R,2R)-2-(azidomethyl)-2,3-dihydro-1H-inden-1-yl)-N²-(4-chloro-3-fluorophenyl) oxalamide

N¹-((1R,2R)-2-(aminomethyl)-2,3-dihydro-1H-inden-1-yl)-N²-(4-chloro-3-fluorophenyl)-oxalamide

(+)-N¹-(4-chloro-3-fluorophenyl)-N²-(trans-2-(guanidinomethyl)indan-1-yl)oxalamide formate salt

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