[(2R,3S,5R)-5-(6-benzamidopurin-9-yl)-2-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]tetrahydrofuran-3-yl] 4-nitrobenzoate

Base Information

Chemical Name:[(2R,3S,5R)-5-(6-benzamidopurin-9-yl)-2-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]tetrahydrofuran-3-yl] 4-nitrobenzoate
CAS No.:606141-34-8
Molecular Formula:C₄₅H₃₈N₆O₉
Molecular Weight:806.832
Hs Code.:

Synonyms:[(2R,3S,5R)-5-(6-benzamidopurin-9-yl)-2-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]tetrahydrofuran-3-yl] 4-nitrobenzoate

Suppliers and Price of [(2R,3S,5R)-5-(6-benzamidopurin-9-yl)-2-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]tetrahydrofuran-3-yl] 4-nitrobenzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [(2R,3S,5R)-5-(6-benzamidopurin-9-yl)-2-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]tetrahydrofuran-3-yl] 4-nitrobenzoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of [(2R,3S,5R)-5-(6-benzamidopurin-9-yl)-2-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]tetrahydrofuran-3-yl] 4-nitrobenzoate

There total 1 articles about [(2R,3S,5R)-5-(6-benzamidopurin-9-yl)-2-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]tetrahydrofuran-3-yl] 4-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.1%

: 64325-78-6
N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine

: 62-23-7
4-nitro-benzoic acid

: 606141-34-8
[(2R,3S,5R)-5-(6-benzamidopurin-9-yl)-2-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]tetrahydrofuran-3-yl] 4-nitrobenzoate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 1.5h; Cooling with ice; Inert atmosphere;

Reference yield: 97.0%

: 606141-34-8
[(2R,3S,5R)-5-(6-benzamidopurin-9-yl)-2-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]tetrahydrofuran-3-yl] 4-nitrobenzoate

: 139260-81-4
N-[9-[(2R,4R,5R)-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-4-hydroxytetrahydrofuran-2-yl]purin-6-yl]benzamide

Guidance literature:: With sodium methylate; In methanol; at 0 ℃; for 1.5h;
DOI:10.1016/S0040-4020(03)00870-6

Reference yield:

: 606141-34-8
[(2R,3S,5R)-5-(6-benzamidopurin-9-yl)-2-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]tetrahydrofuran-3-yl] 4-nitrobenzoate

: 357399-10-1
N⁶-benzoyl-3',5'-diamino-2',3',5'-trideoxyadenosine

Guidance literature:: Multi-step reaction with 5 steps

1: 97 percent / MeONa / methanol / 1.5 h / 0 °C

2: 94 percent / HCO₂H / CHCl₃ / 24 h / 20 °C

3: 75 percent / 4-(N,N-dimethylamino)pyridine; pyridine / 2 h / 20 °C

4: 75 percent / NaN₃ / dimethylformamide / 5 h / 65 °C

5: 81 percent / H₂ / Pd / ethanol / 4 h / 20 °C

With pyridine; dmap; formic acid; sodium azide; hydrogen; sodium methylate; palladium; In methanol; ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(03)00870-6