threo-N-<2-methyl-3-(dimethylphenylsiloxy)-3-phenylpropanoyl>piperidine

Base Information

Chemical Name:threo-N-<2-methyl-3-(dimethylphenylsiloxy)-3-phenylpropanoyl>piperidine
CAS No.:116596-19-1
Molecular Formula:C₂₂H₂₉NO₂Si
Molecular Weight:367.563
Hs Code.:

Synonyms:threo-N-<2-methyl-3-(dimethylphenylsiloxy)-3-phenylpropanoyl>piperidine

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Chemical Property of threo-N-<2-methyl-3-(dimethylphenylsiloxy)-3-phenylpropanoyl>piperidine

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Technology Process of threo-N-<2-methyl-3-(dimethylphenylsiloxy)-3-phenylpropanoyl>piperidine

There total 3 articles about threo-N-<2-methyl-3-(dimethylphenylsiloxy)-3-phenylpropanoyl>piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 766-77-8
Dimethylphenylsilane

: 106181-33-3
2-methyl-1-phenyl-3-(pyrrolidin-1-yl)propane-1,3-dione

: 116596-19-1
threo-N-<2-methyl-3-(dimethylphenylsiloxy)-3-phenylpropanoyl>piperidine

Guidance literature:: With N,N,N,N,N,N-hexamethylphosphoric triamide; tris(diethylamino)sulfonium difluorotrimethylsiliconate; In tetrahydrofuran; at 0 ℃; for 22h;
DOI:10.1021/jo00258a003

Reference yield:

: 4553-05-3
1-pyrrolidin-1-yl-propan-1-one

: 116596-19-1
threo-N-<2-methyl-3-(dimethylphenylsiloxy)-3-phenylpropanoyl>piperidine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) lithium diisopropylamide (LDA) / 1.) THF, -80 deg C, 40 min, 2.) -80 deg C, 1 min

2: 90 percent / tris(diethylamino)sulfonium difluorotrimethylsilicate (TSF), hexamethylphosphoric triamide (HMPA) / tetrahydrofuran / 22 h / 0 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; tris(diethylamino)sulfonium difluorotrimethylsiliconate; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1021/jo00258a003

Reference yield:

: 98-88-4
benzoyl chloride

: 116596-19-1
threo-N-<2-methyl-3-(dimethylphenylsiloxy)-3-phenylpropanoyl>piperidine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) lithium diisopropylamide (LDA) / 1.) THF, -80 deg C, 40 min, 2.) -80 deg C, 1 min

2: 90 percent / tris(diethylamino)sulfonium difluorotrimethylsilicate (TSF), hexamethylphosphoric triamide (HMPA) / tetrahydrofuran / 22 h / 0 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; tris(diethylamino)sulfonium difluorotrimethylsiliconate; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1021/jo00258a003