N-{1-[3-(Bis-hydroxymethyl-methyl-silanyl)-propyl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

Base Information

Chemical Name:N-{1-[3-(Bis-hydroxymethyl-methyl-silanyl)-propyl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide
CAS No.:191086-92-7
Molecular Formula:C₁₇H₂₃N₃O₄Si
Molecular Weight:361.473
Hs Code.:

Synonyms:N-{1-[3-(Bis-hydroxymethyl-methyl-silanyl)-propyl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-{1-[3-(Bis-hydroxymethyl-methyl-silanyl)-propyl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-{1-[3-(Bis-hydroxymethyl-methyl-silanyl)-propyl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

There total 5 articles about N-{1-[3-(Bis-hydroxymethyl-methyl-silanyl)-propyl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 98-88-4
benzoyl chloride

: 191086-86-9
4-Amino-1-[3-(bis-hydroxymethyl-methyl-silanyl)-propyl]-1H-pyrimidin-2-one

: 191086-92-7
N-{1-[3-(Bis-hydroxymethyl-methyl-silanyl)-propyl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

Guidance literature:: With chloro-trimethyl-silane; In pyridine; Ambient temperature;
DOI:10.1021/jo962165p

Reference yield:

: 25855-26-9
1-(prop-2-en-1-yl)pyrimidine-2,4(1H,3H)-dione

: 191086-92-7
N-{1-[3-(Bis-hydroxymethyl-methyl-silanyl)-propyl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) HMDS, trimethylchlorosilane, ammonium sulfate, 2.) H₂PtCl₆, propan-2-ol / 1.) reflux, 5 h, 2.) THF, reflux

2: 62 percent / dimethylformamide / 24 h / 100 - 140 °C

3: 92 percent / diphenyl phosphate / pyridine / 72 h / Ambient temperature

4: 1.) ammonium hydroxide, 2.) potassium carbonate / 1.) dioxane, room temperature, 2.) methanol, room temperature, 12 h

5: 45 percent / trimethylchlorosilane / pyridine / Ambient temperature

With dihydrogen hexachloroplatinate; ammonium hydroxide; ammonium sulfate; chloro-trimethyl-silane; diphenyl hydrogen phosphate; potassium carbonate; isopropyl alcohol; 1,1,1,3,3,3-hexamethyl-disilazane; In pyridine; N,N-dimethyl-formamide;
DOI:10.1021/jo962165p

Reference yield:

: 191086-80-3
1-[3-(Bis-chloromethyl-methyl-silanyl)-propyl]-1H-pyrimidine-2,4-dione

: 191086-92-7
N-{1-[3-(Bis-hydroxymethyl-methyl-silanyl)-propyl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 62 percent / dimethylformamide / 24 h / 100 - 140 °C

2: 92 percent / diphenyl phosphate / pyridine / 72 h / Ambient temperature

3: 1.) ammonium hydroxide, 2.) potassium carbonate / 1.) dioxane, room temperature, 2.) methanol, room temperature, 12 h

4: 45 percent / trimethylchlorosilane / pyridine / Ambient temperature

With ammonium hydroxide; chloro-trimethyl-silane; diphenyl hydrogen phosphate; potassium carbonate; In pyridine; N,N-dimethyl-formamide;
DOI:10.1021/jo962165p