25855-26-9Relevant articles and documents
A new route to acyclic nucleosides via palladium-mediated allylic alkylation and cross-metathesis
Amblard, Franck,Nolan, Steven P.,Gillaizeau, Isabelle,Agrofoglio, Luigi A.
, p. 9177 - 9180 (2003)
A method for the syntheses of E-unsaturated acyclic nucleosides via a combination of palladium-catalyzed allylic alkylation and ruthenium-based cross metathesis is described. This approach provides a concise, efficient and reliable route to new nucleoside
Regioselective synthesis of 1-allyl- and 1-arylmethyl uracil and thymine derivatives
Malik, Vaishali,Singh, Palwinder,Kumar, Subodh
, p. 4009 - 4014 (2005)
2,4-Bis(trimethylsiloxy) pyrimidines 1 with allyl halides and arylmethyl halides in 1,2-dichloroethane in the presence of I2 regioselectively provide 1-allyl-/1-arylmethyl-uracil and thymine derivatives. The secondary aryl alkyl and diaryl meth
The Convenient Synthesis of Unsaturated Nucleoside Analogues in Water under Microwave Irradiation
Xia, Ran,Sun, Li-Ping
, p. 76 - 82 (2016/03/01)
A convenient method for the regioselective synthesis of unsaturated nucleoside analogs in water under microwave irradiation was developed. All pyrimidine and purine nucleoside derivatives were exclusively alkylated at N1 and N9 respectively in good to excellent yields. In addition, this system could tolerate a broad range of functional groups, such as chloro, bromo, iodo, alkyl, amino, and hydroxyl groups. More importantly, the reaction scale could be enlarged to 50 mmol which made this route attractive for industrial application.
A new route to N1-substituted uracil derivatives using hypervalent iodine
Yoshimura, Yuichi,Kan-No, Hiroya,Kiran,Natori, Yoshihiro,Saito, Yukako,Takahata, Hiroki
experimental part, p. 1163 - 1170 (2012/06/04)
In continuation of our previous study, oxidative coupling reactions of uracil with allylsilane or enol ethers were examined using diacetoxyiodobenzene. The reaction of persilylated uracil with 3,4-dihydro-2H-pyran in the presence of TMSOTf and PhI(OAc)res