3-[(phosphonic acid diethyl ester)-methyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-3-methyl ester-6-yl)-benzamide

Base Information

Chemical Name:3-[(phosphonic acid diethyl ester)-methyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-3-methyl ester-6-yl)-benzamide
CAS No.:1282521-20-3
Molecular Formula:C₂₃H₃₁N₂O₈P
Molecular Weight:494.481
Hs Code.:

Synonyms:3-[(phosphonic acid diethyl ester)-methyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-3-methyl ester-6-yl)-benzamide

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Chemical Property of 3-[(phosphonic acid diethyl ester)-methyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-3-methyl ester-6-yl)-benzamide

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Technology Process of 3-[(phosphonic acid diethyl ester)-methyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-3-methyl ester-6-yl)-benzamide

There total 9 articles about 3-[(phosphonic acid diethyl ester)-methyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-3-methyl ester-6-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.3%

: 1282521-23-6
3-bromomethyl-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-3-methyl ester-6-yl)-benzamide

: 122-52-1
triethyl phosphite

: 1282521-20-3
3-[(phosphonic acid diethyl ester)-methyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-3-methyl ester-6-yl)-benzamide

Guidance literature:: at 160 ℃; for 3h;

Reference yield:

: 13036-02-7
Dimethyl 5-hydroxyisophthalate

: 1282521-20-3
3-[(phosphonic acid diethyl ester)-methyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-3-methyl ester-6-yl)-benzamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12 h / 0 - 20 °C

2.1: potassium hydroxide; methanol / 12 h / 100 °C

3.1: borane-THF / tetrahydrofuran / 12 h / 0 - 20 °C

3.2: 3 h / 0 °C

4.1: sodium hydroxide / tetrahydrofuran / 12 h / 20 °C

5.1: pyridine / dichloromethane / 2 h / 0 - 20 °C

6.1: thionyl chloride / 3 h / 100 °C

6.2: 12 h / 20 °C

7.1: potassium carbonate / water; methanol / 2 h / 20 °C

7.2: 12 h / 0 - 20 °C

8.1: 3 h / 160 °C

With pyridine; methanol; thionyl chloride; borane-THF; di-isopropyl azodicarboxylate; potassium carbonate; triphenylphosphine; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;

Reference yield:

: 1282520-90-4
5-(2-methoxy-(1S)-methyl-ethoxy)isophthalic acid monomethyl ester

: 1282521-20-3
3-[(phosphonic acid diethyl ester)-methyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-3-methyl ester-6-yl)-benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: borane-THF / tetrahydrofuran / 12 h / 0 - 20 °C

1.2: 3 h / 0 °C

2.1: sodium hydroxide / tetrahydrofuran / 12 h / 20 °C

3.1: pyridine / dichloromethane / 2 h / 0 - 20 °C

4.1: thionyl chloride / 3 h / 100 °C

4.2: 12 h / 20 °C

5.1: potassium carbonate / water; methanol / 2 h / 20 °C

5.2: 12 h / 0 - 20 °C

6.1: 3 h / 160 °C

With pyridine; thionyl chloride; borane-THF; potassium carbonate; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;