3-bromomethyl-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-3-methyl ester-6-yl)-benzamide

Base Information

Chemical Name:3-bromomethyl-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-3-methyl ester-6-yl)-benzamide
CAS No.:1282521-23-6
Molecular Formula:C₁₉H₂₁BrN₂O₅
Molecular Weight:437.29
Hs Code.:

Synonyms:3-bromomethyl-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-3-methyl ester-6-yl)-benzamide

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Chemical Property of 3-bromomethyl-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-3-methyl ester-6-yl)-benzamide

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Technology Process of 3-bromomethyl-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-3-methyl ester-6-yl)-benzamide

There total 8 articles about 3-bromomethyl-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-3-methyl ester-6-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.4%

: 1282521-22-5
3-acetoxymethyl-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-3-methyl ester-6-yl)-benzamide

: 1282521-23-6
3-bromomethyl-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-3-methyl ester-6-yl)-benzamide

Guidance literature:: 3-acetoxymethyl-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-3-methyl ester-6-yl)-benzamide; With potassium carbonate; In methanol; water; at 20 ℃; for 2h;

With tribromo phosphate; In tetrahydrofuran; at 0 - 20 ℃; for 12h;

Reference yield:

: 13036-02-7
Dimethyl 5-hydroxyisophthalate

: 1282521-23-6
3-bromomethyl-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-3-methyl ester-6-yl)-benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12 h / 0 - 20 °C

2.1: potassium hydroxide; methanol / 12 h / 100 °C

3.1: borane-THF / tetrahydrofuran / 12 h / 0 - 20 °C

3.2: 3 h / 0 °C

4.1: sodium hydroxide / tetrahydrofuran / 12 h / 20 °C

5.1: pyridine / dichloromethane / 2 h / 0 - 20 °C

6.1: thionyl chloride / 3 h / 100 °C

6.2: 12 h / 20 °C

7.1: potassium carbonate / water; methanol / 2 h / 20 °C

7.2: 12 h / 0 - 20 °C

With pyridine; methanol; thionyl chloride; borane-THF; di-isopropyl azodicarboxylate; potassium carbonate; triphenylphosphine; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;

Reference yield:

: 1282520-90-4
5-(2-methoxy-(1S)-methyl-ethoxy)isophthalic acid monomethyl ester

: 1282521-23-6
3-bromomethyl-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-3-methyl ester-6-yl)-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: borane-THF / tetrahydrofuran / 12 h / 0 - 20 °C

1.2: 3 h / 0 °C

2.1: sodium hydroxide / tetrahydrofuran / 12 h / 20 °C

3.1: pyridine / dichloromethane / 2 h / 0 - 20 °C

4.1: thionyl chloride / 3 h / 100 °C

4.2: 12 h / 20 °C

5.1: potassium carbonate / water; methanol / 2 h / 20 °C

5.2: 12 h / 0 - 20 °C

With pyridine; thionyl chloride; borane-THF; potassium carbonate; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;