Toluene-4-sulfonic acid 2,2-dimethyl-6-oxo-cyclohexylmethyl ester

Base Information

• Chemical Name: Toluene-4-sulfonic acid 2,2-dimethyl-6-oxo-cyclohexylmethyl ester
• CAS No.: 134312-48-4
• Molecular Formula: C₁₆H₂₂O₄S
• Molecular Weight: 310.414
• Mol file: 134312-48-4.mol

Synonyms:Toluene-4-sulfonic acid 2,2-dimethyl-6-oxo-cyclohexylmethyl ester

Chemical Property of Toluene-4-sulfonic acid 2,2-dimethyl-6-oxo-cyclohexylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of Toluene-4-sulfonic acid 2,2-dimethyl-6-oxo-cyclohexylmethyl ester

There total 3 articles about Toluene-4-sulfonic acid 2,2-dimethyl-6-oxo-cyclohexylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,3-dimethyl-2-((((4-methylphenyl)sulfonyl)oxy)methyl)cyclohexanol (134312-40-6) → Toluene-4-sulfonic acid 2,2-dimethyl-6-oxo-cyclohexylmethyl ester (134312-48-4)

Guidance literature:

With jones reagent; In acetone; for 0.5h; Yield given; Ambient temperature;

DOI:10.1021/jo00014a032

Reference yield:

methyl 2,2-dimethyl-6-oxocyclohexanecarboxylate (71135-95-0) → Toluene-4-sulfonic acid 2,2-dimethyl-6-oxo-cyclohexylmethyl ester (134312-48-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 77 percent / LiAlH₄ / diethyl ether / 1 h

2: 78 percent / pyridine / 120 h

3: Jones reagent / acetone / 0.5 h / Ambient temperature

With pyridine; lithium aluminium tetrahydride; jones reagent; In diethyl ether; acetone;

DOI:10.1021/jo00014a032

Reference yield:

2-hydroxy-6,6-dimethylcyclohexanemethanol (134312-39-3) → Toluene-4-sulfonic acid 2,2-dimethyl-6-oxo-cyclohexylmethyl ester (134312-48-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / pyridine / 120 h

2: Jones reagent / acetone / 0.5 h / Ambient temperature

With pyridine; jones reagent; In acetone;

DOI:10.1021/jo00014a032

upstream raw materials:

3,3-dimethyl-2-((((4-methylphenyl)sulfonyl)oxy)methyl)cyclohexanol

methyl 2,2-dimethyl-6-oxocyclohexanecarboxylate

2-hydroxy-6,6-dimethylcyclohexanemethanol

Downstream raw materials:

3,3-dimethyl-2-methylenecyclohexanone