3,3-dimethyl-2-((((4-methylphenyl)sulfonyl)oxy)methyl)cyclohexanol

Base Information

• Chemical Name: 3,3-dimethyl-2-((((4-methylphenyl)sulfonyl)oxy)methyl)cyclohexanol
• CAS No.: 134312-40-6
• Molecular Formula: C₁₆H₂₄O₄S
• Molecular Weight: 312.43
• Mol file: 134312-40-6.mol

Synonyms:3,3-dimethyl-2-((((4-methylphenyl)sulfonyl)oxy)methyl)cyclohexanol

Chemical Property of 3,3-dimethyl-2-((((4-methylphenyl)sulfonyl)oxy)methyl)cyclohexanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 3,3-dimethyl-2-((((4-methylphenyl)sulfonyl)oxy)methyl)cyclohexanol

There total 2 articles about 3,3-dimethyl-2-((((4-methylphenyl)sulfonyl)oxy)methyl)cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-hydroxy-6,6-dimethylcyclohexanemethanol (134312-39-3) + p-toluenesulfonyl chloride (98-59-9) → 3,3-dimethyl-2-((((4-methylphenyl)sulfonyl)oxy)methyl)cyclohexanol (134312-40-6)

Guidance literature:

With pyridine; for 120h;

DOI:10.1021/jo00014a032

Reference yield:

methyl 2,2-dimethyl-6-oxocyclohexanecarboxylate (71135-95-0) → 3,3-dimethyl-2-((((4-methylphenyl)sulfonyl)oxy)methyl)cyclohexanol (134312-40-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / LiAlH₄ / diethyl ether / 1 h

2: 78 percent / pyridine / 120 h

With pyridine; lithium aluminium tetrahydride; In diethyl ether;

DOI:10.1021/jo00014a032

Reference yield:

3,3-dimethyl-2-((((4-methylphenyl)sulfonyl)oxy)methyl)cyclohexanol (134312-40-6) → Toluene-4-sulfonic acid 2,2-dimethyl-6-oxo-cyclohexylmethyl ester (134312-48-4)

Guidance literature:

With jones reagent; In acetone; for 0.5h; Yield given; Ambient temperature;

DOI:10.1021/jo00014a032

upstream raw materials:

2-hydroxy-6,6-dimethylcyclohexanemethanol

p-toluenesulfonyl chloride

methyl 2,2-dimethyl-6-oxocyclohexanecarboxylate

Downstream raw materials:

Toluene-4-sulfonic acid 2,2-dimethyl-6-oxo-cyclohexylmethyl ester

3,3-dimethyl-2-methylenecyclohexanone