4-tert-butyl N^α-(1-adamantylcarbonyl)-N-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}-L-aspartamide

Base Information

• Chemical Name: 4-tert-butyl N^α-(1-adamantylcarbonyl)-N-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}-L-aspartamide
• CAS No.: 936749-40-5
• Molecular Formula: C₃₄H₅₂N₄O₅
• Molecular Weight: 596.811

Synonyms:4-tert-butyl N^α-(1-adamantylcarbonyl)-N-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}-L-aspartamide

Chemical Property of 4-tert-butyl N^α-(1-adamantylcarbonyl)-N-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}-L-aspartamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-tert-butyl N^α-(1-adamantylcarbonyl)-N-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}-L-aspartamide

There total 5 articles about 4-tert-butyl N^α-(1-adamantylcarbonyl)-N-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}-L-aspartamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-tert-butyl N-(1-adamantylcarbonyl)-L-aspartate (936749-36-9) + 4-[4-(2-methoxyphenyl)piperazin-1-yl]butylamine (21103-33-3) → 4-tert-butyl Nα-(1-adamantylcarbonyl)-N-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}-L-aspartamide (936749-40-5)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1016/j.bmc.2007.02.018

Reference yield:

1-benzyl 4-tert-butyl N-(1-adamantylcarbonyl)-L-aspartate (936749-33-6) → 4-tert-butyl Nα-(1-adamantylcarbonyl)-N-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}-L-aspartamide (936749-40-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / hydrogen / Pd/C / methanol / 4 h / 20 °C

2: 88 percent / (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium PF₆; triethylamine / CH₂Cl₂ / 12 h / 20 °C

With hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1016/j.bmc.2007.02.018

Reference yield:

Fmoc-(tBu)Asp-OH (71989-14-5) → 4-tert-butyl Nα-(1-adamantylcarbonyl)-N-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}-L-aspartamide (936749-40-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 86 percent / tetrabutylammonium bromide; K₂CO₃ / acetonitrile / 12 h / 20 °C

2: piperidine / dimethylformamide / 1 h / 20 °C

3: 89 percent / (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium PF₆; triethylamine / CH₂Cl₂ / 8 h / 20 °C

4: 93 percent / hydrogen / Pd/C / methanol / 4 h / 20 °C

5: 88 percent / (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium PF₆; triethylamine / CH₂Cl₂ / 12 h / 20 °C

With piperidine; tetrabutylammomium bromide; hydrogen; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.bmc.2007.02.018

upstream raw materials:

4-tert-butyl N-(1-adamantylcarbonyl)-L-aspartate

4-[4-(2-methoxyphenyl)piperazin-1-yl]butylamine

1-benzyl 4-tert-butyl N-(1-adamantylcarbonyl)-L-aspartate

Fmoc-(tBu)Asp-OH

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 936749-40-5 4-tert-butyl N^α-(1-adamantylcarbonyl)-N-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}-L-aspartamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send