2-chloro-N-(4-ethoxyphenyl)acetamide

Base Information

• Chemical Name: 2-chloro-N-(4-ethoxyphenyl)acetamide
• CAS No.: 2153-08-4
• Molecular Formula: C10H12ClNO2
• Molecular Weight: 213.664
• Hs Code.: 2924299090
• NSC Number: 46900
• UNII: X55ZN2ADK2
• DSSTox Substance ID: DTXSID80175866
• Nikkaji Number: J55.013B
• Wikidata: Q83046201
• Mol file: 2153-08-4.mol

Synonyms:2-chloro-N-(4-ethoxyphenyl)acetamide;2153-08-4;2-Chloro-p-acetophenetidide;Acetamide, 2-chloro-N-(4-ethoxyphenyl)-;p-ACETOPHENETIDIDE, 2-CHLORO-;N-(Chloroacetyl)-p-phenetidide;p-Phenetidine, N-chloroacetyl-;X55ZN2ADK2;Acetamide,2-chloro-N-(4-ethoxyphenyl)-;AI3-23575;MFCD00018908;NSC 46900;NSC-46900;BRN 0514356;2-Chloro-N-(4-ethoxy-phenyl)-acetamide;NSC46900;UNII-X55ZN2ADK2;WLN: G1VMR DO2;N-Chloroacetyl-4-ethoxyaniline;alpha-Chloro-p-ethoxyacetanilide;DTXSID80175866;STK119119;AKOS000265703;N-(4-Ethoxyphenyl)-2-chloroacetamide;JS-2986;BB 0217608;FT-0678541;EN300-01572;VU0549360-1;3-13-00-01059 (Beilstein Handbook Reference);SR-01000031880;SR-01000031880-1;Z56821912;F9995-0395

Chemical Property of 2-chloro-N-(4-ethoxyphenyl)acetamide

Chemical Property:

• Vapor Pressure: 3.38E-06mmHg at 25°C
• Refractive Index: 1.563
• Boiling Point: 387.1 °C at 760 mmHg
• Flash Point: 187.9 °C
• PSA: 38.33000
• Density: 1.225 g/cm³
• LogP: 2.33560
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 213.0556563
• Heavy Atom Count: 14
• Complexity: 179

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-N-(4-ethoxyphenyl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCOC1=CC=C(C=C1)NC(=O)CCl

Technology Process of 2-chloro-N-(4-ethoxyphenyl)acetamide

There total 4 articles about 2-chloro-N-(4-ethoxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

chloroacetyl chloride (79-04-9) + 4-Ethoxyaniline (156-43-4) → 2-chloro-4'-ethoxyacetanilide (2153-08-4)

Guidance literature:

4-Ethoxyaniline; With potassium acetate; acetic acid; at 0 - 5 ℃;

chloroacetyl chloride; at 20 ℃; for 0.5h;

Reference yield:

→ 2-chloro-4'-ethoxyacetanilide (2153-08-4)

Guidance literature:

With phosphorus pentoxide;

Reference yield:

4-Ethoxyaniline (156-43-4) + Chloroacetamide (79-07-2) → 2-chloro-4'-ethoxyacetanilide (2153-08-4)

Guidance literature:

at 160 - 170 ℃;

upstream raw materials:

chloroacetyl chloride

4-Ethoxyaniline

Chloroacetamide

Downstream raw materials:

2-(4-ethoxy-anilino)-thiazol-4-one

(4-ethoxy-phenylcarbamimidoylmercapto)-acetic acid

N,N-diethyl-glycine p-phenetidide

N,N'-bis-(4-ethoxy-phenyl)-2-chloro-acetamidine

Refernces

• 1、 Hashim, Syed Riaz,Hegde, Rahul Rama,Pal, Dilipkumar,Rani, Priyanka. "New Mercaptoacetamide Derivatives: Synthesis and Assessment as Antimicrobial and Antimycobacterial Agents". . p. 715 - 723. Retrieved 2021/10/27.
• 2、 Sonawane, Vinay R.,Siddique, Mohd Usman Mohd,Gatchie, Linda,Williams, Ibidapo S.,Bharate, Sandip B.,Jayaprakash, Venkatesan,Sinha, Barij N.,Chaudhuri, Bhabatosh. "CYP enzymes, expressed within live human suspension cells, are superior to widely-used microsomal enzymes in identifying potent CYP1A1/CYP1B1 inhibitors: Identification of quinazolinones as CYP1A1/CYP1B1 inhibitors that efficiently reverse B[a]P toxicity and cisplatin resistance". . p. 177 - 194. Retrieved 2019/02/27.