(R)-2-((S)-1-{(S)-2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-1-phenyl-ethyl}-1,2,3,6-tetrahydro-pyridin-2-yl)-1-phenyl-ethanol

Base Information

Chemical Name:(R)-2-((S)-1-{(S)-2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-1-phenyl-ethyl}-1,2,3,6-tetrahydro-pyridin-2-yl)-1-phenyl-ethanol
CAS No.:237059-15-3
Molecular Formula:C₂₉H₄₃NO₂Si
Molecular Weight:465.751
Hs Code.:

Synonyms:(R)-2-((S)-1-{(S)-2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-1-phenyl-ethyl}-1,2,3,6-tetrahydro-pyridin-2-yl)-1-phenyl-ethanol

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Chemical Property of (R)-2-((S)-1-{(S)-2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-1-phenyl-ethyl}-1,2,3,6-tetrahydro-pyridin-2-yl)-1-phenyl-ethanol

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Technology Process of (R)-2-((S)-1-{(S)-2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-1-phenyl-ethyl}-1,2,3,6-tetrahydro-pyridin-2-yl)-1-phenyl-ethanol

There total 7 articles about (R)-2-((S)-1-{(S)-2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-1-phenyl-ethyl}-1,2,3,6-tetrahydro-pyridin-2-yl)-1-phenyl-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 100-59-4
phenylmagnesium chloride

: 208832-22-8
(1S,2S)-(-)-(1-<2--1-phenylethyl>-1,2,3,6-tetrahydropyridin-2-yl)-ethanal

: 237059-14-2
(1S,2S)-(-)-2-(1-<2--1-phenylethyl>-1,2,3,6-tetrahydropyridin-2-yl)-1-phenylethanol

: 237059-15-3
(R)-2-((S)-1-{(S)-2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-1-phenyl-ethyl}-1,2,3,6-tetrahydro-pyridin-2-yl)-1-phenyl-ethanol

Guidance literature:: In diethyl ether; Ambient temperature;
DOI:10.1021/jo981912a

Reference yield:

: 67373-56-2
chlorodimethyl(1,1,2-trimethylpropyl)silane

: 237059-15-3
(R)-2-((S)-1-{(S)-2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-1-phenyl-ethyl}-1,2,3,6-tetrahydro-pyridin-2-yl)-1-phenyl-ethanol

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / NEt₃, DMAP / CH₂Cl₂ / Ambient temperature

2: 89 percent / LiAlH₄ / tetrahydrofuran / Ambient temperature

3: 1.) DMSO, (COCl)2, 2.) NEt₃ / 1.) CH₂Cl₂, -78 deg C, 15 min, 2.) -78 deg C to room temperature

4: 32 percent / diethyl ether / Ambient temperature

With dmap; lithium aluminium tetrahydride; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/jo981912a

Reference yield:

: 126366-29-8
(3S,8aS)-(+)-3-phenyl-2,3,8,8a-tetrahydro-5H-oxazolo<3,2-a>pyridine

: 237059-15-3
(R)-2-((S)-1-{(S)-2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-1-phenyl-ethyl}-1,2,3,6-tetrahydro-pyridin-2-yl)-1-phenyl-ethanol

Guidance literature:: Multi-step reaction with 5 steps

1: 30 percent / diethyl ether / Ambient temperature

2: 90 percent / NEt₃, DMAP / CH₂Cl₂ / Ambient temperature

3: 89 percent / LiAlH₄ / tetrahydrofuran / Ambient temperature

4: 1.) DMSO, (COCl)2, 2.) NEt₃ / 1.) CH₂Cl₂, -78 deg C, 15 min, 2.) -78 deg C to room temperature

5: 32 percent / diethyl ether / Ambient temperature

With dmap; lithium aluminium tetrahydride; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/jo981912a