S-n-butyl 4-fluorobenzothioate

Base Information

• Chemical Name: S-n-butyl 4-fluorobenzothioate
• CAS No.: 348-03-8
• Molecular Formula: C₁₁H₁₃FOS
• Molecular Weight: 212.288
• Mol file: 348-03-8.mol

Synonyms:S-n-butyl 4-fluorobenzothioate

Chemical Property of S-n-butyl 4-fluorobenzothioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of S-n-butyl 4-fluorobenzothioate

There total 3 articles about S-n-butyl 4-fluorobenzothioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

n-butanethiol (109-79-5) + 4-fluorobenzaldehyde (459-57-4) → S-n-butyl 4-fluorobenzothioate (348-03-8)

Guidance literature:

With dmap; 4-methyl-3-(2,4,6-trimethylphenyl)thiazolium tetrafluoroborate; tetrabutylammomium bromide; In acetonitrile; at 45 ℃; for 24h; chemoselective reaction; Catalytic behavior; Inert atmosphere; Electrochemical reaction;

DOI:10.1021/ol500459x

Reference yield:

4-fluorobenzoyl chloride (403-43-0) → S-n-butyl 4-fluorobenzothioate (348-03-8)

Guidance literature:

Multi-step reaction with 2 steps

2: ethanolic KOH-solution

With potassium hydroxide;

DOI:10.1021/ja01218a057

Reference yield:

1-bromo-butane (109-65-9) + 4-fluoro-thiobenzoic acid (403-44-1) → S-n-butyl 4-fluorobenzothioate (348-03-8)

Guidance literature:

With potassium hydroxide;

DOI:10.1021/ja01218a057

upstream raw materials:

1-bromo-butane

4-fluoro-thiobenzoic acid

4-fluorobenzoyl chloride

n-butanethiol

Downstream raw materials:

4-fluorobenzoyl fluoride

Refernces