3-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]pyridine-4-carboxylic acid methyl ester

Base Information

Chemical Name:3-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]pyridine-4-carboxylic acid methyl ester
CAS No.:1610889-92-3
Molecular Formula:C₁₆H₁₄F₃NO₂S
Molecular Weight:341.354
Hs Code.:

Synonyms:3-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]pyridine-4-carboxylic acid methyl ester

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Chemical Property of 3-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]pyridine-4-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 3-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]pyridine-4-carboxylic acid methyl ester

There total 8 articles about 3-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]pyridine-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 98273-79-1
3-chloropyridine-4-carboxylic acid methyl ester

: 1610889-87-6
3,3-difluoro-3-(4-fluorophenyl)propane-1-thiol

: 1610889-92-3
3-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]pyridine-4-carboxylic acid methyl ester

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 1h; Sealed tube;

Reference yield:

: 1242643-03-3
acetic acid [3,3-difluoro-3-(4-fluorophenyl)propyl] ester

: 1610889-92-3
3-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]pyridine-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: water; sodium hydroxide / ethanol / 1 h / 0 - 20 °C

2: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 0 - 20 °C

3: N,N-dimethyl-formamide / 1.5 h / 60 °C

4: water; sodium hydroxide / ethanol / 1 h / 0 - 20 °C

5: caesium carbonate / N,N-dimethyl-formamide / 1 h / 90 °C / Sealed tube

With carbon tetrabromide; water; caesium carbonate; triphenylphosphine; sodium hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1242643-02-2
acetic acid 2-[2-(4-fluorophenyl)-[1,3]dithiolan-2-yl]ethyl ester

: 1610889-92-3
3-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]pyridine-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; pyridine hydrofluoride / dichloromethane / 3.5 h / -78 - 20 °C

2: water; sodium hydroxide / ethanol / 1 h / 0 - 20 °C

3: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 0 - 20 °C

4: N,N-dimethyl-formamide / 1.5 h / 60 °C

5: water; sodium hydroxide / ethanol / 1 h / 0 - 20 °C

6: caesium carbonate / N,N-dimethyl-formamide / 1 h / 90 °C / Sealed tube

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; carbon tetrabromide; pyridine hydrofluoride; water; caesium carbonate; triphenylphosphine; sodium hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide;