98273-79-1

Basic information

• Product Name: Methyl 3-chloroisonicotinate
• Synonyms: Methyl 3-chloroisonicotinate;3-Chloropyridine-4-carboxylic acid methyl ester;Methyl 3-chloropyridine-4-carboxylate;3-Chloro-4-pyridinecarboxylic acid methyl ester;Methyl 3-chloronicotinate
• CAS NO: 98273-79-1
• Molecular Formula: C₇H₆ClNO₂
• Molecular Weight: 171.58
• Product Categories: pharmacetical
• Mol File: 98273-79-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 70-75℃ (0.1 Torr)
• Flash Point: 94.7°C
• Appearance: /
• Density: 1.294g/cm³
• Vapor Pressure: 0.057mmHg at 25°C
• Refractive Index: 1.53425 (589.3 nm 20℃)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: Methyl 3-chloroisonicotinate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-chloroisonicotinate(98273-79-1)
• EPA Substance Registry System: Methyl 3-chloroisonicotinate(98273-79-1)

Safety Data

• Hazardous Substances Data: 98273-79-1(Hazardous Substances Data)

Usage

General Description

Methyl 3-chloroisonicotinate is a chemical compound that belongs to the class of pyridine derivatives. It is a derivative of nicotinic acid and is commonly used in the synthesis of pharmaceuticals and agrochemicals. Methyl 3-chloroisonicotinate is a versatile building block in organic synthesis due to its reactivity and ability to undergo various chemical reactions. Methyl 3-chloroisonicotinate is also known for its potential biological activities and is being studied for its pharmacological properties, including its potential as an anti-inflammatory and anti-cancer agent. Overall, this compound holds promise for various applications in the fields of medicine, agriculture, and chemical research.

InChI:InChI=1/C7H6ClNO2/c1-11-7(10)5-2-3-9-4-6(5)8/h2-4H,1H3

Upstream product

• 186581-53-3 diazomethane 
• 88912-27-0 3-chloro-isonicotinic acid 
• 67-56-1 methanol 
• 188677-48-7 3-Chloro-N-phenyl-isonicotinamide 
• 3034-31-9 N-phenylisonicotinamide 
• 626-60-8 3-Chloropyridine 
• 74-88-4 methyl iodide 
• 10128-71-9 3-hydroxyisonicotinic acid 

Downstream Products

• 662150-32-5 methyl-3-[4-(methylsulfanyl)benzyl]isonicotinate 
• 1610889-92-3 3-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]pyridine-4-carboxylic acid methyl ester 
• 1177423-36-7 C₂₆H₂₅N₃O₅ 
• 1177423-34-5 C₂₇H₂₇N₃O₅ 
• 1177423-33-4 C₂₄H₂₃N₃O₄ 
• 1177423-30-1 C₂₃H₂₀N₂O₅ 
• 1177423-29-8 C₂₄H₂₂N₂O₅ 
• 1177423-28-7 C₂₁H₁₆N₂O₅ 
• 1177423-26-5 C₁₉H₁₂N₂O₄ 
• 1177423-27-6 C₁₉H₁₄N₂O₄ 
• 79698-53-6 (3-chloropyridin-4-yl)methanol 
• 1035690-01-7 methyl 3-(3'-ethoxy-3-fluorobiphenyl-4-ylamino)isonicotinate 
• 188622-60-8 3-(2-Chloro-5-fluoro-benzyl)-isonicotinic acid 
• 188622-61-9 3-(5-Chloro-2-fluoro-benzyl)-isonicotinic acid 

Relevant articles and documents

Spin-Center Shift-Enabled Direct Enantioselective α-Benzylation of Aldehydes with Alcohols

Nature routinely engages alcohols as leaving groups, as DNA biosynthesis relies on the removal of water from ribonucleoside diphosphates by a radical-mediated "spin-center shift" (SCS) mechanism. Alcohols, however, remain underused as alkylating agents in synthetic chemistry due to their low reactivity in two-electron pathways. We report herein an enantioselective α-benzylation of aldehydes using alcohols as alkylating agents based on the mechanistic principle of spin-center shift. This strategy harnesses the dual activation modes of photoredox and organocatalysis, engaging the alcohol by SCS and capturing the resulting benzylic radical with a catalytically generated enamine. Mechanistic studies provide evidence for SCS as a key elementary step, identify the origins of competing reactions, and enable improvements in chemoselectivity by rational photocatalyst design.

FUSED HETEROARYL MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-KB ACTIVITY AND USE THEREOF

Novel non-steroidal compounds are provided which are useful in treating diseases or disorders associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity, including metabolic and inflammatory and immune diseases or disorders, ha

Application of organolithium compounds in organic synthesis. Part 19. Synthetic strategies based on aromatic metallation. A concise regiospecific synthesis of 3-halogenated picolinic and isonicotinic acids

The synthesis of the halogenated picolin- and isonicotinalides (3) and (4) via metallation (n-BuLi) of the anilides (1) and (2) and then the reaction of the generated bis-lithiated anilides with halogenating agents (CCl3-CCl3, CH2Br-CH2Br, I2) followed by subsequent acidic hydrolysis of (3) and (4), as a way of regiospecific transformation of picoline and isonicotine acids into their C3-halogenated derivatives, is described.