5-(4-[3-(hexahydro-1H-azepin-1-yl)propoxy]phenyl)-1-pentanol

Base Information

• Chemical Name: 5-(4-[3-(hexahydro-1H-azepin-1-yl)propoxy]phenyl)-1-pentanol
• CAS No.: 955360-13-1
• Molecular Formula: C₂₀H₃₃NO₂
• Molecular Weight: 319.488
• Mol file: 955360-13-1.mol

Synonyms:5-(4-[3-(hexahydro-1H-azepin-1-yl)propoxy]phenyl)-1-pentanol

Chemical Property of 5-(4-[3-(hexahydro-1H-azepin-1-yl)propoxy]phenyl)-1-pentanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4-[3-(hexahydro-1H-azepin-1-yl)propoxy]phenyl)-1-pentanol

There total 2 articles about 5-(4-[3-(hexahydro-1H-azepin-1-yl)propoxy]phenyl)-1-pentanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(3-hydroxypropyl)hexahydro-1H-azepine (29194-89-6) → 5-(4-[3-(hexahydro-1H-azepin-1-yl)propoxy]phenyl)-1-pentanol (955360-13-1)

Guidance literature:

Multi-step reaction with 2 steps

1: di-tert-butyl-diazodicarboxylate; triphenylphosphine / tetrahydrofuran / -20 - 75 °C

2: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 0.27 h / Inert atmosphere

With lithium aluminium tetrahydride; di-tert-butyl-diazodicarboxylate; triphenylphosphine; In tetrahydrofuran; diethyl ether; 1: Mitsunobu reaction;

DOI:10.1021/jm1013874

Reference yield:

5-(4-hydroxyphenyl)pentanoic acid methyl ester (64201-30-5) → 5-(4-[3-(hexahydro-1H-azepin-1-yl)propoxy]phenyl)-1-pentanol (955360-13-1)

Guidance literature:

Multi-step reaction with 2 steps

1: di-tert-butyl-diazodicarboxylate; triphenylphosphine / tetrahydrofuran / -20 - 75 °C

2: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 0.27 h / Inert atmosphere

With lithium aluminium tetrahydride; di-tert-butyl-diazodicarboxylate; triphenylphosphine; In tetrahydrofuran; diethyl ether; 1: Mitsunobu reaction;

DOI:10.1021/jm1013874

Reference yield: 100.0%

5-(4-[3-(hexahydro-1H-azepin-1-yl)propoxy]phenyl)-1-pentanol (955360-13-1) + methanesulfonyl chloride (124-63-0) → 5-(4-[3-(hexahydro-1H-azepin-1-yl)propoxy]phenyl)pentyl methanesulfonate (955360-14-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/jm1013874

upstream raw materials:

1-(3-hydroxypropyl)hexahydro-1H-azepine

5-(4-hydroxyphenyl)pentanoic acid methyl ester

Downstream raw materials:

5-(4-[3-(hexahydro-1H-azepin-1-yl)propoxy]phenyl)pentyl methanesulfonate