5-Bromo-4-fluoro-1H-benzimidazole 95%

Base Information

• Chemical Name: 5-Bromo-4-fluoro-1H-benzimidazole 95%
• CAS No.: 1008361-72-5
• Molecular Formula: C₇H₄BrFN₂
• Molecular Weight: 215.025
• Hs Code.: 2933998090
• Mol file: 1008361-72-5.mol

Synonyms:5-bromo-4-fluoro-1H-benzo[d]imidazole

Chemical Property of 5-Bromo-4-fluoro-1H-benzimidazole 95%

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

5-Bromo-4-fluoro-1H-benzimidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Bromo-4-fluoro-1H-benzimidazole 95%

There total 4 articles about 5-Bromo-4-fluoro-1H-benzimidazole 95% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formic acid (64-18-6) + 4-bromo-3-fluoro-benzene-1,2-diamine (886762-86-3) → 5-bromo-4-fluoro-1H-benzo[d]imidazole (1008361-72-5)

Guidance literature:

formic acid; 4-bromo-3-fluoro-benzene-1,2-diamine; for 7h; Reflux;

With sodium hydroxide;

Reference yield:

3-fluoro-2-nitro-phenylamine → 5-bromo-4-fluoro-1H-benzo[d]imidazole (1008361-72-5)

Guidance literature:

Multi-step reaction with 3 steps

1: N-Bromosuccinimide / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

2: tin(II) chloride dihdyrate / ethanol / 4 h / Reflux

3: 1.5 h / Reflux

With N-Bromosuccinimide; tin(II) chloride dihdyrate; In ethanol; N,N-dimethyl-formamide;

Reference yield:

4-bromo-3-fluoro-2-nitro-phenylamine (886762-75-0) → 5-bromo-4-fluoro-1H-benzo[d]imidazole (1008361-72-5)

Guidance literature:

Multi-step reaction with 2 steps

1: tin(II) chloride dihdyrate / ethanol / 4 h / Reflux

2: 1.5 h / Reflux

With tin(II) chloride dihdyrate; In ethanol;

upstream raw materials:

formic acid

4-bromo-3-fluoro-benzene-1,2-diamine

2,6-difluoro-1-nitrobenzene

4-bromo-3-fluoro-2-nitro-phenylamine

Downstream raw materials:

6-bromo-7-fluoro-1-(triphenylmethyl)-1H-benzimidazole

Refernces

• 1、 -. "PYRIDIN-2-ONE DERIVATIVES OF FORMULA (I) USEFUL AS EP3 RECEPTOR ANTAGONISTS". Page/Page column 0681-0682. . Retrieved 2019/02/24.
• 2、 Crawford, James J.,Lee, Wendy,Aliagas, Ignacio,Mathieu, Simon,Hoeflich, Klaus P.,Zhou, Wei,Wang, Weiru,Rouge, Lionel,Murray, Lesley,La, Hank,Liu, Ning,Fan, Peter W.,Cheong, Jonathan,Heise, Christopher E.,Ramaswamy, Sreemathy,Mintzer, Robert,Liu, Yanzhou,Chao, Qi,Rudolph, Joachim. "Structure-Guided Design of Group i Selective p21-Activated Kinase Inhibitors". . p. 5121 - 5136. Retrieved 2015/07/02.