Thiobenzoic acid S-[(2S,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester

Base Information

• Chemical Name: Thiobenzoic acid S-[(2S,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester
• CAS No.: 174466-94-5
• Molecular Formula: C₁₇H₁₈N₂O₅S
• Molecular Weight: 362.406
• Mol file: 174466-94-5.mol

Synonyms:Thiobenzoic acid S-[(2S,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester

Chemical Property of Thiobenzoic acid S-[(2S,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of Thiobenzoic acid S-[(2S,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester

There total 1 articles about Thiobenzoic acid S-[(2S,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

thiobenzoic acid (98-91-9) + thymidine (50-89-5,28854-96-8,3545-96-8,50-88-4) → Thiobenzoic acid S-[(2S,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester (174466-94-5)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine;

DOI:10.1080/07328319708006228

Reference yield: 74.0%

bis(2-nitrophenyl)disulfide (1155-00-6) + Thiobenzoic acid S-[(2S,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester (174466-94-5) → 5'-deoxy-5'-S-(2-nitrophenyldisulfanyl)thymidine

Guidance literature:

With N-butylamine; In dichloromethane;

DOI:10.1016/0040-4020(95)00936-1

Reference yield: 73.0%

5,5'-dinitro-2,2'-disulfanediyl-bis-pyridine (2127-10-8) + Thiobenzoic acid S-[(2S,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester (174466-94-5) → 5'-deoxy-5'-S-(5-nitropyridyl-2-disulfanyl)thymidine

Guidance literature:

With N-butylamine; In dichloromethane;

DOI:10.1016/0040-4020(95)00936-1

upstream raw materials:

thiobenzoic acid

thymidine

Downstream raw materials:

5'-thio-thymidine

C₄₁H₄₄N₄O₁₀S₂

C₄₇H₅₈N₄O₁₀S₂Si