3,5-Dimethyl-4-isoxazolamine

Base Information

• Chemical Name: 3,5-Dimethyl-4-isoxazolamine
• CAS No.: 31329-64-3
• Molecular Formula: C5H8N2O
• Molecular Weight: 112.131
• Hs Code.: 2934999090
• Mol file: 31329-64-3.mol

Synonyms:Isoxazole,4-amino-3,5-dimethyl- (6CI,7CI,8CI);3,5-Dimethyl-4-aminoisoxazole;3,5-Dimethylisoxazol-4-amine;3,5-Dimethylisoxazol-4-ylamine;4-Amino-3,5-dimethylisoxazole;

Chemical Property of 3,5-Dimethyl-4-isoxazolamine

Chemical Property:

• Vapor Pressure: 0.056mmHg at 25°C
• Melting Point: 41-46 °C(lit.)
• Refractive Index: 1.52
• Boiling Point: 233.4 °C at 760 mmHg
• PKA: 1.59±0.10(Predicted)
• Flash Point: 95 °C
• PSA: 52.05000
• Density: 1.118 g/cm³
• LogP: 1.45480
• Storage Temp.: ?20°C

Purity/Quality:

97% ^*data from raw suppliers

3,5-Dimethylisoxazol-4-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Amino-3,5-dimethylisoxazole may be used in the synthesis of 3,5-dimethyl-4-phenylazoisoxazole via reaction with nitrosobenzene.The diazonium salt of 4-Amino-3,5-dimethylisoxazole can react with cupric sulfate to form acetyltriazole derivatives.

Technology Process of 3,5-Dimethyl-4-isoxazolamine

There total 4 articles about 3,5-Dimethyl-4-isoxazolamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

3,5-dimethyl-4-nitroisoxazole (1123-49-5) → 3,5-dimethylisoxazol-4-amine (31329-64-3)

Guidance literature:

With ammonium chloride; zinc; In water; at 0 - 5 ℃;

DOI:10.1002/hlca.19910740309

Reference yield:

3,5-dimethyl-1,2-oxazole (300-87-8) → 3,5-dimethylisoxazol-4-amine (31329-64-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / HNO₃, H₂SO₄ / 110 °C

2: 82 percent / Zn, NH₄Cl / H₂O / 0 - 5 °C

With sulfuric acid; nitric acid; ammonium chloride; zinc; In water;

DOI:10.1002/hlca.19910740309

Reference yield:

acetylacetone (123-54-6,81235-32-7) → 3,5-dimethylisoxazol-4-amine (31329-64-3)

Guidance literature:

Multi-step reaction with 3 steps

1: hydroxylamine

2: HNO₃+H₂SO₄

3: amalgamated aluminium; diethyl ether

With diethyl ether; aluminium amalgam; sulfuric acid; hydroxylamine; nitric acid;

upstream raw materials:

3,5-dimethyl-4-nitroisoxazole

3,5-dimethyl-1,2-oxazole

acetylacetone

Downstream raw materials:

4-Acetamino-3,5-dimethyl-isoxazol

N-(3,5-dimethylisoxazol-4-yl)benzamide

4-amino-N-(3,5-dimethyl-isoxazol-4-yl)-benzenesulfonamide

1-(5-methyl-1H-[1,2,3]triazol-4-yl)-ethanone