[6,2'-bis-benzyloxy-5'-N-tert-butylsulfamoyl-5-(5-carbamimidoyl-1H-benzimidazolyl-2-yl)biphenyl-3-yl]acetic acid methyl ester hydrochloride

Base Information

Chemical Name:[6,2'-bis-benzyloxy-5'-N-tert-butylsulfamoyl-5-(5-carbamimidoyl-1H-benzimidazolyl-2-yl)biphenyl-3-yl]acetic acid methyl ester hydrochloride
CAS No.:871266-69-2
Molecular Formula:C₄₁H₄₁N₅O₆S*ClH
Molecular Weight:768.333
Hs Code.:

[6,2'-bis-benzyloxy-5'-N-tert-butylsulfamoyl-5-(5-carbamimidoyl-1H-benzimidazolyl-2-yl)biphenyl-3-yl]acetic acid methyl ester hydrochloride

Synonyms:[6,2'-bis-benzyloxy-5'-N-tert-butylsulfamoyl-5-(5-carbamimidoyl-1H-benzimidazolyl-2-yl)biphenyl-3-yl]acetic acid methyl ester hydrochloride

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Chemical Property of [6,2'-bis-benzyloxy-5'-N-tert-butylsulfamoyl-5-(5-carbamimidoyl-1H-benzimidazolyl-2-yl)biphenyl-3-yl]acetic acid methyl ester hydrochloride

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Technology Process of [6,2'-bis-benzyloxy-5'-N-tert-butylsulfamoyl-5-(5-carbamimidoyl-1H-benzimidazolyl-2-yl)biphenyl-3-yl]acetic acid methyl ester hydrochloride

There total 14 articles about [6,2'-bis-benzyloxy-5'-N-tert-butylsulfamoyl-5-(5-carbamimidoyl-1H-benzimidazolyl-2-yl)biphenyl-3-yl]acetic acid methyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 871266-68-1
(6,2'-bisbenzyloxy-5'-N-tert-butylsulfamoyl-5-formylbiphenyl-3-yl)acetic acid methyl ester

: 3,4-diaminobenzamidine monohydrochloride

: 871266-69-2
[6,2'-bis-benzyloxy-5'-N-tert-butylsulfamoyl-5-(5-carbamimidoyl-1H-benzimidazolyl-2-yl)biphenyl-3-yl]acetic acid methyl ester hydrochloride

Guidance literature:: (6,2'-bisbenzyloxy-5'-N-tert-butylsulfamoyl-5-formylbiphenyl-3-yl)acetic acid methyl ester; With sodium hydrogensulfite; In methanol; water; at 60 ℃; for 2.5h;

3,4-diaminobenzamidine monohydrochloride; In methanol; water; at 60 ℃; Product distribution / selectivity;

Reference yield:

: 871266-68-1
(6,2'-bisbenzyloxy-5'-N-tert-butylsulfamoyl-5-formylbiphenyl-3-yl)acetic acid methyl ester

: 68827-43-0
4-amidino-1,2-phenylenediamine

: 871266-69-2
[6,2'-bis-benzyloxy-5'-N-tert-butylsulfamoyl-5-(5-carbamimidoyl-1H-benzimidazolyl-2-yl)biphenyl-3-yl]acetic acid methyl ester hydrochloride

Guidance literature:: With sodium metabisulfite; dichloro bis(acetonitrile) palladium(II); oxygen; In water; isopropyl alcohol; Reflux;

Reference yield:

: 61874-04-2
(3-formyl-4-hydroxyphenyl)acetic acid methyl ester

: 871266-69-2
[6,2'-bis-benzyloxy-5'-N-tert-butylsulfamoyl-5-(5-carbamimidoyl-1H-benzimidazolyl-2-yl)biphenyl-3-yl]acetic acid methyl ester hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: N-Bromosuccinimide / N,N-dimethyl-formamide / 4 h / 5 - 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 14 h / Reflux

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; diisopropylamine / tetrahydrofuran / 16 h / Inert atmosphere; Reflux

4: sodium metabisulfite; oxygen; dichloro bis(acetonitrile) palladium(II) / water; isopropyl alcohol / Reflux

With sodium metabisulfite; dichloro bis(acetonitrile) palladium(II); N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; oxygen; diisopropylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;