cis-5-<2-(dimethylamino)ethyl>-2,3-dihydro-2-(4-methoxyphenyl)-3-methyl-1,5-benzothiazepin-4(5H)-one hydrochloride

Base Information

Chemical Name:cis-5-<2-(dimethylamino)ethyl>-2,3-dihydro-2-(4-methoxyphenyl)-3-methyl-1,5-benzothiazepin-4(5H)-one hydrochloride
CAS No.:129152-05-2
Molecular Formula:C₂₁H₂₆N₂O₂S*ClH
Molecular Weight:406.977
Hs Code.:

Synonyms:cis-5-<2-(dimethylamino)ethyl>-2,3-dihydro-2-(4-methoxyphenyl)-3-methyl-1,5-benzothiazepin-4(5H)-one hydrochloride

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Chemical Property of cis-5-<2-(dimethylamino)ethyl>-2,3-dihydro-2-(4-methoxyphenyl)-3-methyl-1,5-benzothiazepin-4(5H)-one hydrochloride

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Technology Process of cis-5-<2-(dimethylamino)ethyl>-2,3-dihydro-2-(4-methoxyphenyl)-3-methyl-1,5-benzothiazepin-4(5H)-one hydrochloride

There total 7 articles about cis-5-<2-(dimethylamino)ethyl>-2,3-dihydro-2-(4-methoxyphenyl)-3-methyl-1,5-benzothiazepin-4(5H)-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 4584-46-7
(2-chloroethyl)dimethylamine hydrochloride

: 129152-04-1
cis-2,3-dihydro-2-(4-methoxyphenyl)-3-methyl-1,5-benzothiazepin-4(5H)-one

: 129152-05-2
cis-5-<2-(dimethylamino)ethyl>-2,3-dihydro-2-(4-methoxyphenyl)-3-methyl-1,5-benzothiazepin-4(5H)-one hydrochloride

Guidance literature:: With potassium carbonate; In butanone; for 18h; Heating;
DOI:10.1021/jo00308a013

Reference yield:

: 21118-89-8
2-<(4-methoxyphenyl)methyl>-2-methylpropanedioic acid, dimethyl ester

: 129152-05-2
cis-5-<2-(dimethylamino)ethyl>-2,3-dihydro-2-(4-methoxyphenyl)-3-methyl-1,5-benzothiazepin-4(5H)-one hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: 87 percent / N-bromosuccinimide, azobis(isobutrylnitrile) / CCl₄ / 3 h / Irradiation

2: 1) NaH / 1) DMF, 30 min, 2) r.t., overnight

3: 58 percent / NaH / paraffin; dimethylsulfoxide / 16 h

4: 86.7 percent / KOH / methanol / 24 h / Heating

5: 57 percent / p-TsOH*H₂O / dimethylsulfoxide / 2 h / 75 °C

6: 61 percent / K₂CO₃ / butan-2-one / 18 h / Heating

With potassium hydroxide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydride; potassium carbonate; toluene-4-sulfonic acid; In methanol; tetrachloromethane; dimethyl sulfoxide; butanone; paraffin;
DOI:10.1021/jo00308a013

Reference yield:

: 129152-00-7
2--2-methylpropanedioic acid, dimethyl ester

: 129152-05-2
cis-5-<2-(dimethylamino)ethyl>-2,3-dihydro-2-(4-methoxyphenyl)-3-methyl-1,5-benzothiazepin-4(5H)-one hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: 1) NaH / 1) DMF, 30 min, 2) r.t., overnight

2: 58 percent / NaH / paraffin; dimethylsulfoxide / 16 h

3: 86.7 percent / KOH / methanol / 24 h / Heating

4: 57 percent / p-TsOH*H₂O / dimethylsulfoxide / 2 h / 75 °C

5: 61 percent / K₂CO₃ / butan-2-one / 18 h / Heating

With potassium hydroxide; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; In methanol; dimethyl sulfoxide; butanone; paraffin;
DOI:10.1021/jo00308a013