(4-Hydroxymethyl-phenyl)-carbamic acid 4-{(S)-6-allyloxycarbonylamino-2-[(S)-2-((R)-2-allyloxycarbonylamino-propionylamino)-3-(1H-indol-3-yl)-propionylamino]-hexanoylamino}-benzyl ester

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Chemical Name:(4-Hydroxymethyl-phenyl)-carbamic acid 4-{(S)-6-allyloxycarbonylamino-2-[(S)-2-((R)-2-allyloxycarbonylamino-propionylamino)-3-(1H-indol-3-yl)-propionylamino]-hexanoylamino}-benzyl ester
CAS No.:393523-20-1
Molecular Formula:C₄₃H₅₁N₇O₁₀
Molecular Weight:825.919
Hs Code.:

(4-Hydroxymethyl-phenyl)-carbamic acid 4-{(S)-6-allyloxycarbonylamino-2-[(S)-2-((R)-2-allyloxycarbonylamino-propionylamino)-3-(1H-indol-3-yl)-propionylamino]-hexanoylamino}-benzyl ester

Synonyms:(4-Hydroxymethyl-phenyl)-carbamic acid 4-{(S)-6-allyloxycarbonylamino-2-[(S)-2-((R)-2-allyloxycarbonylamino-propionylamino)-3-(1H-indol-3-yl)-propionylamino]-hexanoylamino}-benzyl ester

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Chemical Property of (4-Hydroxymethyl-phenyl)-carbamic acid 4-{(S)-6-allyloxycarbonylamino-2-[(S)-2-((R)-2-allyloxycarbonylamino-propionylamino)-3-(1H-indol-3-yl)-propionylamino]-hexanoylamino}-benzyl ester

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Technology Process of (4-Hydroxymethyl-phenyl)-carbamic acid 4-{(S)-6-allyloxycarbonylamino-2-[(S)-2-((R)-2-allyloxycarbonylamino-propionylamino)-3-(1H-indol-3-yl)-propionylamino]-hexanoylamino}-benzyl ester

There total 8 articles about (4-Hydroxymethyl-phenyl)-carbamic acid 4-{(S)-6-allyloxycarbonylamino-2-[(S)-2-((R)-2-allyloxycarbonylamino-propionylamino)-3-(1H-indol-3-yl)-propionylamino]-hexanoylamino}-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 623-04-1
4-aminobenzenemethanol

: 393523-17-6
Carbonic acid 4-{(S)-6-allyloxycarbonylamino-2-[(S)-2-((R)-2-allyloxycarbonylamino-propionylamino)-3-(1H-indol-3-yl)-propionylamino]-hexanoylamino}-benzyl ester 4-nitro-phenyl ester

: 393523-20-1
(4-Hydroxymethyl-phenyl)-carbamic acid 4-{(S)-6-allyloxycarbonylamino-2-[(S)-2-((R)-2-allyloxycarbonylamino-propionylamino)-3-(1H-indol-3-yl)-propionylamino]-hexanoylamino}-benzyl ester

Guidance literature:: With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 48h;
DOI:10.1021/jo0158884

Reference yield:

: 13288-57-8
1,1-dimethylethyl N₆-{[(1,1-dimethylethyl)oxy]carbonyl}-L-lysinate hydrochloride

: 393523-20-1
(4-Hydroxymethyl-phenyl)-carbamic acid 4-{(S)-6-allyloxycarbonylamino-2-[(S)-2-((R)-2-allyloxycarbonylamino-propionylamino)-3-(1H-indol-3-yl)-propionylamino]-hexanoylamino}-benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 86 percent / Et₃N / CH₂Cl₂ / 5 h / 20 °C

2.1: 2 M NaOH / dioxane; methanol / 1 h / 20 °C

2.2: 69 percent / Et₃N / CH₂Cl₂ / 16 h / 0 °C

3.1: HCl / ethyl acetate / 5 h

4.1: 302 mg / Et₃N / H₂O; acetonitrile / pH 8

5.1: N-methylmorpholine; isobutyl chloroformate / tetrahydrofuran / 2 h / -40 - -30 °C

5.2: 94 percent / N-methylmorpholine / tetrahydrofuran / 2 h

6.1: 67 percent / pyridine / tetrahydrofuran; CH₂Cl₂ / 48 h / 20 °C

7.1: 89 percent / DIPEA; N-hydroxybenzotriazole / dimethylformamide / 48 h

With 4-methyl-morpholine; pyridine; hydrogenchloride; sodium hydroxide; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo0158884

Reference yield:

: 84771-20-0
2,5-dioxopyrrolidin-1-yl (((9H-fluoren-9-yl)methoxy)carbonyl)-L-tryptophanate

: 393523-20-1
(4-Hydroxymethyl-phenyl)-carbamic acid 4-{(S)-6-allyloxycarbonylamino-2-[(S)-2-((R)-2-allyloxycarbonylamino-propionylamino)-3-(1H-indol-3-yl)-propionylamino]-hexanoylamino}-benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 86 percent / Et₃N / CH₂Cl₂ / 5 h / 20 °C

2.1: 2 M NaOH / dioxane; methanol / 1 h / 20 °C

2.2: 69 percent / Et₃N / CH₂Cl₂ / 16 h / 0 °C

3.1: HCl / ethyl acetate / 5 h

4.1: 302 mg / Et₃N / H₂O; acetonitrile / pH 8

5.1: N-methylmorpholine; isobutyl chloroformate / tetrahydrofuran / 2 h / -40 - -30 °C

5.2: 94 percent / N-methylmorpholine / tetrahydrofuran / 2 h

6.1: 67 percent / pyridine / tetrahydrofuran; CH₂Cl₂ / 48 h / 20 °C

7.1: 89 percent / DIPEA; N-hydroxybenzotriazole / dimethylformamide / 48 h

With 4-methyl-morpholine; pyridine; hydrogenchloride; sodium hydroxide; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo0158884