Carbonic acid 4-{(S)-6-allyloxycarbonylamino-2-[(S)-2-((R)-2-allyloxycarbonylamino-propionylamino)-3-(1H-indol-3-yl)-propionylamino]-hexanoylamino}-benzyl ester 4-nitro-phenyl ester

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Chemical Name:Carbonic acid 4-{(S)-6-allyloxycarbonylamino-2-[(S)-2-((R)-2-allyloxycarbonylamino-propionylamino)-3-(1H-indol-3-yl)-propionylamino]-hexanoylamino}-benzyl ester 4-nitro-phenyl ester
CAS No.:393523-17-6
Molecular Formula:C₄₂H₄₇N₇O₁₂
Molecular Weight:841.875
Hs Code.:

Carbonic acid 4-{(S)-6-allyloxycarbonylamino-2-[(S)-2-((R)-2-allyloxycarbonylamino-propionylamino)-3-(1H-indol-3-yl)-propionylamino]-hexanoylamino}-benzyl ester 4-nitro-phenyl ester

Synonyms:Carbonic acid 4-{(S)-6-allyloxycarbonylamino-2-[(S)-2-((R)-2-allyloxycarbonylamino-propionylamino)-3-(1H-indol-3-yl)-propionylamino]-hexanoylamino}-benzyl ester 4-nitro-phenyl ester

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Chemical Property of Carbonic acid 4-{(S)-6-allyloxycarbonylamino-2-[(S)-2-((R)-2-allyloxycarbonylamino-propionylamino)-3-(1H-indol-3-yl)-propionylamino]-hexanoylamino}-benzyl ester 4-nitro-phenyl ester

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Technology Process of Carbonic acid 4-{(S)-6-allyloxycarbonylamino-2-[(S)-2-((R)-2-allyloxycarbonylamino-propionylamino)-3-(1H-indol-3-yl)-propionylamino]-hexanoylamino}-benzyl ester 4-nitro-phenyl ester

There total 7 articles about Carbonic acid 4-{(S)-6-allyloxycarbonylamino-2-[(S)-2-((R)-2-allyloxycarbonylamino-propionylamino)-3-(1H-indol-3-yl)-propionylamino]-hexanoylamino}-benzyl ester 4-nitro-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 7693-46-1
4-Nitrophenyl chloroformate

: 393523-14-3
[(S)-5-[(S)-2-((R)-2-Allyloxycarbonylamino-propionylamino)-3-(1H-indol-3-yl)-propionylamino]-5-(4-hydroxymethyl-phenylcarbamoyl)-pentyl]-carbamic acid allyl ester

: 393523-17-6
Carbonic acid 4-{(S)-6-allyloxycarbonylamino-2-[(S)-2-((R)-2-allyloxycarbonylamino-propionylamino)-3-(1H-indol-3-yl)-propionylamino]-hexanoylamino}-benzyl ester 4-nitro-phenyl ester

Guidance literature:: With pyridine; In tetrahydrofuran; dichloromethane; at 20 ℃; for 48h;
DOI:10.1021/jo0158884

Reference yield:

: 13288-57-8
1,1-dimethylethyl N₆-{[(1,1-dimethylethyl)oxy]carbonyl}-L-lysinate hydrochloride

: 393523-17-6
Carbonic acid 4-{(S)-6-allyloxycarbonylamino-2-[(S)-2-((R)-2-allyloxycarbonylamino-propionylamino)-3-(1H-indol-3-yl)-propionylamino]-hexanoylamino}-benzyl ester 4-nitro-phenyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 86 percent / Et₃N / CH₂Cl₂ / 5 h / 20 °C

2.1: 2 M NaOH / dioxane; methanol / 1 h / 20 °C

2.2: 69 percent / Et₃N / CH₂Cl₂ / 16 h / 0 °C

3.1: HCl / ethyl acetate / 5 h

4.1: 302 mg / Et₃N / H₂O; acetonitrile / pH 8

5.1: N-methylmorpholine; isobutyl chloroformate / tetrahydrofuran / 2 h / -40 - -30 °C

5.2: 94 percent / N-methylmorpholine / tetrahydrofuran / 2 h

6.1: 67 percent / pyridine / tetrahydrofuran; CH₂Cl₂ / 48 h / 20 °C

With 4-methyl-morpholine; pyridine; hydrogenchloride; sodium hydroxide; triethylamine; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; acetonitrile;
DOI:10.1021/jo0158884

Reference yield:

: 84771-20-0
2,5-dioxopyrrolidin-1-yl (((9H-fluoren-9-yl)methoxy)carbonyl)-L-tryptophanate

: 393523-17-6
Carbonic acid 4-{(S)-6-allyloxycarbonylamino-2-[(S)-2-((R)-2-allyloxycarbonylamino-propionylamino)-3-(1H-indol-3-yl)-propionylamino]-hexanoylamino}-benzyl ester 4-nitro-phenyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 86 percent / Et₃N / CH₂Cl₂ / 5 h / 20 °C

2.1: 2 M NaOH / dioxane; methanol / 1 h / 20 °C

2.2: 69 percent / Et₃N / CH₂Cl₂ / 16 h / 0 °C

3.1: HCl / ethyl acetate / 5 h

4.1: 302 mg / Et₃N / H₂O; acetonitrile / pH 8

5.1: N-methylmorpholine; isobutyl chloroformate / tetrahydrofuran / 2 h / -40 - -30 °C

5.2: 94 percent / N-methylmorpholine / tetrahydrofuran / 2 h

6.1: 67 percent / pyridine / tetrahydrofuran; CH₂Cl₂ / 48 h / 20 °C

With 4-methyl-morpholine; pyridine; hydrogenchloride; sodium hydroxide; triethylamine; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; acetonitrile;
DOI:10.1021/jo0158884