methyl 2-[[4-fluoro-2-(2-hydroxymethylcyclopropyl)benzenesulfonyl]-(2-methoxyethoxymethyl)amino]-5,6,7,8-tetrahydronaphthalene-1-carboxylate

Base Information

Chemical Name:methyl 2-[[4-fluoro-2-(2-hydroxymethylcyclopropyl)benzenesulfonyl]-(2-methoxyethoxymethyl)amino]-5,6,7,8-tetrahydronaphthalene-1-carboxylate
CAS No.:904679-60-3
Molecular Formula:C₂₆H₃₂FNO₇S
Molecular Weight:521.607
Hs Code.:

methyl 2-[[4-fluoro-2-(2-hydroxymethylcyclopropyl)benzenesulfonyl]-(2-methoxyethoxymethyl)amino]-5,6,7,8-tetrahydronaphthalene-1-carboxylate

Synonyms:methyl 2-[[4-fluoro-2-(2-hydroxymethylcyclopropyl)benzenesulfonyl]-(2-methoxyethoxymethyl)amino]-5,6,7,8-tetrahydronaphthalene-1-carboxylate

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Chemical Property of methyl 2-[[4-fluoro-2-(2-hydroxymethylcyclopropyl)benzenesulfonyl]-(2-methoxyethoxymethyl)amino]-5,6,7,8-tetrahydronaphthalene-1-carboxylate

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Technology Process of methyl 2-[[4-fluoro-2-(2-hydroxymethylcyclopropyl)benzenesulfonyl]-(2-methoxyethoxymethyl)amino]-5,6,7,8-tetrahydronaphthalene-1-carboxylate

There total 8 articles about methyl 2-[[4-fluoro-2-(2-hydroxymethylcyclopropyl)benzenesulfonyl]-(2-methoxyethoxymethyl)amino]-5,6,7,8-tetrahydronaphthalene-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.7%

: 904679-59-0
methyl 2-[(2-bromo-4-fluorobenzenesulfonyl)-(2-methoxyethoxymethyl)amino]-5,6,7,8-tetrahydronaphthalene-1-carboxylate

: (2-tributylstannylcyclopropyl)methanol

: 904679-60-3
methyl 2-[[4-fluoro-2-(2-hydroxymethylcyclopropyl)benzenesulfonyl]-(2-methoxyethoxymethyl)amino]-5,6,7,8-tetrahydronaphthalene-1-carboxylate

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In toluene; at 90 ℃;
DOI:10.1021/jm0601001

Reference yield:

: 947-65-9
methyl 2-hydroxy-1-naphthoate

: 904679-60-3
methyl 2-[[4-fluoro-2-(2-hydroxymethylcyclopropyl)benzenesulfonyl]-(2-methoxyethoxymethyl)amino]-5,6,7,8-tetrahydronaphthalene-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 70 percent / H₂ / Pd/C / methanol; H₂O / 2.5 h / 60 °C / 77572.2 Torr

2.1: pyridine / CH₂Cl₂ / -20 - 20 °C

3.1: 54.06 g / Cs₂CO₃; Pd(OAc)2; 4,5-bis-diphenylphosphanyl-9,9-dimethyl-9H-xanthene / dioxane / 4 h / 100 °C

4.1: 100 percent / aq. HCl / tetrahydrofuran / 1 h / 20 °C

5.1: pyridine / 20 °C

6.1: NaH / tetrahydrofuran / 20 °C

6.2: 87.5 percent / tetrahydrofuran / 20 °C

7.1: 52.7 percent / Pd(PtBu₃)2; Pd₂dba3 / toluene / 90 °C

With pyridine; hydrogenchloride; palladium diacetate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾; hydrogen; sodium hydride; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; dichloromethane; water; toluene; 3.1: Buchwald reaction;
DOI:10.1021/jm0601001

Reference yield:

: 351003-45-7
2-bromo-4-fluorobenzene-1-sulfonyl chloride

: 904679-60-3
methyl 2-[[4-fluoro-2-(2-hydroxymethylcyclopropyl)benzenesulfonyl]-(2-methoxyethoxymethyl)amino]-5,6,7,8-tetrahydronaphthalene-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / 20 °C

2.1: NaH / tetrahydrofuran / 20 °C

2.2: 87.5 percent / tetrahydrofuran / 20 °C

3.1: 52.7 percent / Pd(PtBu₃)2; Pd₂dba3 / toluene / 90 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾; sodium hydride; In tetrahydrofuran; pyridine; toluene;
DOI:10.1021/jm0601001