methyl 3-[1-(4-chloro-2,5-dimethyl-phenylsulfonyl)-piperidin-2-yl]-propionate

Base Information

• Chemical Name: methyl 3-[1-(4-chloro-2,5-dimethyl-phenylsulfonyl)-piperidin-2-yl]-propionate
• CAS No.: 1021204-95-4
• Molecular Formula: C₁₇H₂₄ClNO₄S
• Molecular Weight: 373.901
• Mol file: 1021204-95-4.mol

Synonyms:methyl 3-[1-(4-chloro-2,5-dimethyl-phenylsulfonyl)-piperidin-2-yl]-propionate

Chemical Property of methyl 3-[1-(4-chloro-2,5-dimethyl-phenylsulfonyl)-piperidin-2-yl]-propionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-[1-(4-chloro-2,5-dimethyl-phenylsulfonyl)-piperidin-2-yl]-propionate

There total 5 articles about methyl 3-[1-(4-chloro-2,5-dimethyl-phenylsulfonyl)-piperidin-2-yl]-propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

methyl 3-(piperidin-2-yl)propionate hydrochloride (1021204-94-3) + 4-chloro-2,5-dimethylbenzene-1-sulfonyl chloride (88-49-3) → methyl 3-[1-(4-chloro-2,5-dimethyl-phenylsulfonyl)-piperidin-2-yl]-propionate (1021204-95-4)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

Reference yield: 82.0%

4-chloro-2,5-dimethylbenzene-1-sulfonyl chloride (88-49-3) + 3-[2]piperidyl-propionic acid ; hydrochloride (99310-43-7) → methyl 3-[1-(4-chloro-2,5-dimethyl-phenylsulfonyl)-piperidin-2-yl]-propionate (1021204-95-4)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

methyl 3-(pyridin-2-yl)acrylate (50610-14-5) → methyl 3-[1-(4-chloro-2,5-dimethyl-phenylsulfonyl)-piperidin-2-yl]-propionate (1021204-95-4)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / platinum(IV) oxide / tetrahydrofuran; chloroform / 6000.6 Torr / Inert atmosphere

2: triethylamine / dichloromethane / 20 °C

With hydrogen; triethylamine; platinum(IV) oxide; In tetrahydrofuran; dichloromethane; chloroform;

upstream raw materials:

methyl 3-(piperidin-2-yl)propionate hydrochloride

4-chloro-2,5-dimethylbenzene-1-sulfonyl chloride

3-[2]piperidyl-propionic acid ; hydrochloride

methyl 3-(pyridin-2-yl)acrylate

Downstream raw materials:

3-[1-(4-chloro-2,5-dimethyl-phenylsulfonyl)-piperidin-2-yl]-propionic acid

N-((1-(3-(1-(4-chloro-2,5-dimethylphenylsulfonyl)piperidin-2-yl)propanoyl)-4-(4-methylpiperazin-1-yl)piperidin-4-yl)methyl)acetamide