1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-4-((2-oxo-5-(4-(phosphonomethylphosphinoyl)phenyl)-1,3-dioxol-4-yl)methyl)piperazin-1-yl)-4-oxoquinoline-3-carboxylic acid monotriethylammonium salt

Base Information

Chemical Name:1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-4-((2-oxo-5-(4-(phosphonomethylphosphinoyl)phenyl)-1,3-dioxol-4-yl)methyl)piperazin-1-yl)-4-oxoquinoline-3-carboxylic acid monotriethylammonium salt
CAS No.:1072452-91-5
Molecular Formula:C₆H₁₅N*C₃₀H₃₂FN₃O₁₂P₂
Molecular Weight:808.735
Hs Code.:

1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-4-((2-oxo-5-(4-(phosphonomethylphosphinoyl)phenyl)-1,3-dioxol-4-yl)methyl)piperazin-1-yl)-4-oxoquinoline-3-carboxylic acid monotriethylammonium salt

Synonyms:1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-4-((2-oxo-5-(4-(phosphonomethylphosphinoyl)phenyl)-1,3-dioxol-4-yl)methyl)piperazin-1-yl)-4-oxoquinoline-3-carboxylic acid monotriethylammonium salt

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Chemical Property of 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-4-((2-oxo-5-(4-(phosphonomethylphosphinoyl)phenyl)-1,3-dioxol-4-yl)methyl)piperazin-1-yl)-4-oxoquinoline-3-carboxylic acid monotriethylammonium salt

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Technology Process of 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-4-((2-oxo-5-(4-(phosphonomethylphosphinoyl)phenyl)-1,3-dioxol-4-yl)methyl)piperazin-1-yl)-4-oxoquinoline-3-carboxylic acid monotriethylammonium salt

There total 8 articles about 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-4-((2-oxo-5-(4-(phosphonomethylphosphinoyl)phenyl)-1,3-dioxol-4-yl)methyl)piperazin-1-yl)-4-oxoquinoline-3-carboxylic acid monotriethylammonium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 925685-01-4
1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-4-((2-oxo-5-(4-(O-ethyl(diethylphosphonomethyl)phosphonoyl)phenyl)-1,3-dioxol-4-yl)methyl)piperazin-1-yl)-4-oxoquinoline-3-carboxylic acid

: 15715-58-9
triethylamine carbonate

: 1072452-91-5
1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-4-((2-oxo-5-(4-(phosphonomethylphosphinoyl)phenyl)-1,3-dioxol-4-yl)methyl)piperazin-1-yl)-4-oxoquinoline-3-carboxylic acid monotriethylammonium salt

Guidance literature:: 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-4-((2-oxo-5-(4-(O-ethyl(diethylphosphonomethyl)phosphonoyl)phenyl)-1,3-dioxol-4-yl)methyl)piperazin-1-yl)-4-oxoquinoline-3-carboxylic acid; With trimethylsilyl bromide; In dichloromethane; at 20 ℃; for 15h;

triethylamine carbonate; With triethylamine; In water; pH=6;

Reference yield:

: 481632-29-5
1-(4-bromophenyl)-1-oxopropan-2-yl formate

: 1072452-91-5
1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-4-((2-oxo-5-(4-(phosphonomethylphosphinoyl)phenyl)-1,3-dioxol-4-yl)methyl)piperazin-1-yl)-4-oxoquinoline-3-carboxylic acid monotriethylammonium salt

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide; water / methanol / 18 h

2.1: 1,2-dichloro-ethane; toluene / 0.25 h / 0 °C

2.2: 21 h / 0 - 70 °C

3.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / 3 h / 90 °C

4.1: N-Bromosuccinimide; 1,1'-azobis(1-cyanocyclohexanenitrile) / tetrachloromethane / 4 h / Heating / reflux; strong visible light

5.1: N,N-dimethyl-formamide / 16 h / 20 °C

6.1: trimethylsilyl bromide / dichloromethane / 15 h / 20 °C

6.2: pH 6

With sodium hydroxide; N-Bromosuccinimide; trimethylsilyl bromide; water; triethylamine; 1,1'-azobis(1-cyanocyclohexanenitrile); tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; tetrachloromethane; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 925684-98-6
4-(4-bromophenyl)-5-methyl-1,3-dioxol-2-one

: 1072452-91-5
1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-4-((2-oxo-5-(4-(phosphonomethylphosphinoyl)phenyl)-1,3-dioxol-4-yl)methyl)piperazin-1-yl)-4-oxoquinoline-3-carboxylic acid monotriethylammonium salt

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / 3 h / 90 °C

2.1: N-Bromosuccinimide; 1,1'-azobis(1-cyanocyclohexanenitrile) / tetrachloromethane / 4 h / Heating / reflux; strong visible light

3.1: N,N-dimethyl-formamide / 16 h / 20 °C

4.1: trimethylsilyl bromide / dichloromethane / 15 h / 20 °C

4.2: pH 6

With N-Bromosuccinimide; trimethylsilyl bromide; triethylamine; 1,1'-azobis(1-cyanocyclohexanenitrile); tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;